Minyi Shi

TL;DR: The Encyclopedia of DNA Elements project provides new insights into the organization and regulation of the authors' genes and genome, and is an expansive resource of functional annotations for biomedical research.

TL;DR: The combinatorial, co-association of transcription factors is found to be highly context specific: distinct combinations of factors bind at specific genomic locations.

TL;DR: An overview of the project and the resources it is generating and the application of ENCODE data to interpret the human genome are provided.

TL;DR: In this paper, the binding sites of RNA polymerase II (PolII) and a key regulator of immune responses, nuclear factor κB (p65), were mapped in 10 lymphoblastoid cell lines, and 25 and 7.5% of the respective binding regions were found to differ between individuals.

TL;DR: Analysis of stable enhancers identified a new, essential role for a constitutively expressed, lineage-restricted ETS-family transcription factor, EHF, in epidermal differentiation, suggesting that lineage-specific chromatin structure is established in tissue progenitor cells and is further remodeled in terminal differentiation.