Ryan M. McDaniell

TL;DR: The Encyclopedia of DNA Elements project provides new insights into the organization and regulation of the authors' genes and genome, and is an expansive resource of functional annotations for biomedical research.

TL;DR: An overview of the project and the resources it is generating and the application of ENCODE data to interpret the human genome are provided.

TL;DR: FAIRE has utility as a positive selection for genomic regions associated with regulatory activity, including regions traditionally detected by nuclease hypersensitivity assays, and strongly enriches DNA coincident with the location of DNaseI hypersensitive sites, transcriptional start sites, and active promoters.

TL;DR: Gene expression and RNA Pol II binding data support the hypothesis that COREs control gene activity required for the maintenance of cell-type identity, and it is shown that open chromatin regions bound by CTCF are potent insulators.

TL;DR: This study cataloged both individual-to-individual variation and differences between homologous chromosomes within the same individual (allele-specific variation) in chromatin structure and transcription factor binding in lymphoblastoid cells derived from individuals of geographically diverse ancestry and shows that heritable chromatin status and transcriptionfactor binding differ as a result of genetic variation and may underlie phenotypic variation in humans.