B
Brendan Doe
Researcher at Wellcome Trust Sanger Institute
Publications - 20
Citations - 2289
Brendan Doe is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Gene & CRISPR. The author has an hindex of 11, co-authored 19 publications receiving 1736 citations. Previous affiliations of Brendan Doe include Wellcome Trust.
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Journal ArticleDOI
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson,Ann M. Flenniken,Xiao Ji,Lydia Teboul,Michael D. Wong,Jacqueline K. White,Terrence F. Meehan,Wolfgang Weninger,Henrik Westerberg,Hibret A. Adissu,Candice N. Baker,Lynette Bower,James M. Brown,L. Brianna Caddle,Francesco Chiani,Dave Clary,James Cleak,Mark J. Daly,James M. Denegre,Brendan Doe,Mary E. Dolan,Sarah M. Edie,Helmut Fuchs,Valerie Gailus-Durner,Antonella Galli,Alessia Gambadoro,Juan Gallegos,Shiying Guo,Neil R. Horner,Chih-Wei Hsu,Sara Johnson,Sowmya Kalaga,Lance C. Keith,Louise Lanoue,Thomas N. Lawson,Monkol Lek,Monkol Lek,Manuel Mark,Susan Marschall,Jeremy Mason,Melissa L. McElwee,Susan Newbigging,Lauryl M. J. Nutter,Kevin A. Peterson,Ramiro Ramirez-Solis,Douglas J. Rowland,Edward Ryder,Kaitlin E. Samocha,Kaitlin E. Samocha,John R. Seavitt,Mohammed Selloum,Zsombor Szoke-Kovacs,Masaru Tamura,Amanda G. Trainor,Ilinca Tudose,Shigeharu Wakana,Jonathan Warren,Olivia Wendling,David B. West,Leeyean Wong,Atsushi Yoshiki,Daniel G. MacArthur,Daniel G. MacArthur,Glauco P. Tocchini-Valentini,Xiang Gao,Paul Flicek,Allan Bradley,William C. Skarnes,Monica J. Justice,Helen Parkinson,Mark W. Moore,Sara Wells,Robert E. Braun,Karen L. Svenson,Martin Hrabé de Angelis,Yann Herault,Timothy J. Mohun,Ann-Marie Mallon,R. Mark Henkelman,Steve D.M. Brown,David J. Adams,Kevin C K Lloyd,Colin McKerlie,Arthur L. Beaudet,Maja Bucan,Stephen A. Murray +85 more
TL;DR: It is shown that human disease genes are enriched for essential genes, thus providing a dataset that facilitates the prioritization and validation of mutations identified in clinical sequencing efforts and reveals that incomplete penetrance and variable expressivity are common even on a defined genetic background.
Journal ArticleDOI
Juno is the egg Izumo receptor and is essential for mammalian fertilization
TL;DR: It is shown that the Izumo1–Juno interaction is conserved within several mammalian species, including humans, and it is proposed to rename it Juno to provide opportunities for the rational development of new fertility treatments and contraceptives.
Journal ArticleDOI
The mammalian gene function resource: the international knockout mouse consortium
Allan Bradley,Konstantinos Anastassiadis,Abdelkader Ayadi,James F. Battey,Cindy Bell,Marie-Christine Birling,Joanna Bottomley,Steve D.M. Brown,Antje Bürger,Carol J. Bult,Wendy Bushell,Francis S. Collins,Christian Desaintes,Brendan Doe,Aris N. Economides,Janan T. Eppig,Richard H. Finnell,Richard H. Finnell,Colin Fletcher,Martin Fray,David Frendewey,Roland H. Friedel,Roland H. Friedel,Frank Grosveld,Jens Hansen,Yann Herault,Geoffrey G. Hicks,Andreas Hörlein,Richard Houghton,Martin Hrabé de Angelis,Danny Huylebroeck,Vivek Iyer,Pieter J. de Jong,James A. Kadin,Cornelia Kaloff,Karen Kennedy,Manousos Koutsourakis,Kevin C K Lloyd,Susan Marschall,Jeremy Mason,Colin McKerlie,Michael P. McLeod,Harald von Melchner,Mark Moore,Alejandro O. Mujica,Alejandro O. Mujica,Andras Nagy,Mikhail Nefedov,Lauryl M. J. Nutter,Guillaume Pavlovic,Jane Peterson,Jonathan D. Pollock,Ramiro Ramirez-Solis,Derrick E. Rancourt,Marcello Raspa,Jacques E. Remacle,Martin Ringwald,Barry Rosen,Nadia Rosenthal,Janet Rossant,Patricia Ruiz Noppinger,Edward Ryder,Joel Schick,Frank Schnütgen,Paul N. Schofield,Claudia Seisenberger,Mohammed Selloum,Elizabeth M. Simpson,William C. Skarnes,Damian Smedley,Damian Smedley,William L. Stanford,A. Francis Stewart,Kevin R. Stone,Kate Swan,Hamsa D. Tadepally,Lydia Teboul,Glauco P. Tocchini-Valentini,David M. Valenzuela,Anthony P. West,Ken Ichi Yamamura,Yuko Yoshinaga,Wolfgang Wurst,Wolfgang Wurst +83 more
TL;DR: The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.
Journal ArticleDOI
C13orf31 (FAMIN) is a central regulator of immunometabolic function
M. Zaeem Cader,Katharina Boroviak,Qifeng Zhang,Ghazaleh Assadi,Sarah L. Kempster,Gavin W. Sewell,Svetlana Saveljeva,Jonathan W. Ashcroft,Simon Clare,Subhankar Mukhopadhyay,Karen Brown,Markus Tschurtschenthaler,Tim Raine,Brendan Doe,Edwin R. Chilvers,Jules L. Griffin,Nicole C. Kaneider,R. Andres Floto,Mauro D'Amato,Mauro D'Amato,Allan Bradley,Michael J.O. Wakelam,Gordon Dougan,Arthur Kaser +23 more
TL;DR: FAMIN is identified a central regulator of the metabolic function and bioenergetic state of macrophages that is under evolutionary selection and determines the risk of inflammatory and infectious disease.
Journal ArticleDOI
No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice
Vivek Iyer,Katharina Boroviak,Mark G. Thomas,Brendan Doe,Laura Riva,Edward Ryder,David J. Adams +6 more
TL;DR: If CRISPR mutagenesis were causing SNV or indel off-target mutations in treated embryos, then the number of these mutations is not statistically distinguishable from the background rate of DNMs occurring due to other processes.