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Angela L. Williamson
Researcher at Washington University in St. Louis
Publications - 21
Citations - 1709
Angela L. Williamson is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Ancylostoma caninum & Necator americanus. The author has an hindex of 19, co-authored 21 publications receiving 1660 citations. Previous affiliations of Angela L. Williamson include University of Queensland & George Washington University.
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Journal ArticleDOI
Digestive proteases of blood-feeding nematodes
TL;DR: This review will focus on the digestive proteases of the major blood-feeding nematodes - hookworms and the ruminant parasite, Haemonchus contortus - but also compares and contrasts these proteases with recent findings from schistosomes and malaria parasites.
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Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals
Jeffrey M. Bethony,Alex Loukas,Michael J. Smout,Simon Brooker,Susana Mendez,Jordan L. Plieskatt,Gaddam Goud,Maria Elena Bottazzi,Bin Zhan,Yan Wang,Angela L. Williamson,Sara Lustigman,Rodrigo Correa-Oliveira,Shu-Hua Xiao,Peter J. Hotez +14 more
TL;DR: Support is provided for the development of an effective recombinant vaccine against hookworm infection in humans by examining the antibody responses of individuals from hookworm endemic areas of Brazil and China against the most abundant L3 secreted antigens, the ancylostoma secreted proteins, ASP‐1 and ASP‐2.
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A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms.
Angela L. Williamson,Paolo Lecchi,Benjamin E. Turk,Youngchool Choe,Peter J. Hotez,James H. McKerrow,Lewis C. Cantley,Mohammed Sajid,Charles S. Craik,Alex Loukas +9 more
TL;DR: The semi-ordered pathway of Hb digestion described here is surprisingly similar to that used by Plasmodium to digest Hb and provides a potential mechanism by which these hemoglobinases are efficacious vaccines in animal models of hookworm infection.
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Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative.
Peter J. Hotez,Bin Zhan,Jeffrey M. Bethony,Alex Loukas,Angela L. Williamson,Gaddam Goud,John M. Hawdon,Azra Dobardzic,Reshad Dobardzic,Kashinath Ghosh,Maria Elena Bottazzi,Susana Mendez,Bernard C. Zook,Yan Wang,Sen Liu,Sen Liu,Idong Essiet-Gibson,Sophia Chung-Debose,Shu-Hua Xiao,David P. Knox,Michael M. Meagher,Mehmet Inan,Rodrigo Correa-Oliveira,Paul Vilk,Herman R Shepherd,Walter E. Brandt,Philip K. Russell +26 more
TL;DR: Despite the inability of the human host to develop naturally acquired immune responses to hookworm, there is evidence for the feasibility of developing a vaccine based on the successes of immunising laboratory animals with either attenuated larval vaccines or antigens extracted from the alimentary canal of adult blood-feeding stages
Journal ArticleDOI
Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificity
Angela L. Williamson,Angela L. Williamson,Paul J. Brindley,Giovanni Abbenante,Paul Prociv,Colin Berry,Karen Girdwood,David I. Pritchard,David P. Fairlie,Peter J. Hotez,John P. Dalton,Alex Loukas,Alex Loukas +12 more
TL;DR: It is shown that a cathepsin D‐like protease from the canine hookworm Ancylosotoma caninum (Ac‐APR‐1) and the orthologous proteases from the human hookworm Necator americanus (Na‐ APR‐ 1) are expressed in the gut and probably exert their proteolytic activity extracellularly.