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Antonija Kuzmanic
Researcher at University College London
Publications - 18
Citations - 1136
Antonija Kuzmanic is an academic researcher from University College London. The author has contributed to research in topics: Molecular dynamics & Crystallization. The author has an hindex of 11, co-authored 18 publications receiving 781 citations. Previous affiliations of Antonija Kuzmanic include Max F. Perutz Laboratories.
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Determination of Ensemble-Average Pairwise Root Mean-Square Deviation from Experimental B-Factors
Antonija Kuzmanic,Bojan Zagrovic +1 more
TL;DR: In this paper, the root mean square deviation (RMSD) after roto-translational least-squares fitting is used to measure global structural similarity of macromolecules used commonly.
Journal ArticleDOI
Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
María Isabel Hernández-Alvarez,David Sebastián,David Sebastián,Sara Vives,Saška Ivanova,Saška Ivanova,Paola Bartoccioni,Pamela A. Kakimoto,Natàlia Plana,Sonia R. Veiga,Vanessa Hernández,Nuno Vasconcelos,Gopal Peddinti,Anna Adrover,Mariona Jové,Reinald Pamplona,Isabel Gordaliza-Alaguero,Isabel Gordaliza-Alaguero,Enrique Calvo,Noemí Cabré,Rui E. Castro,Antonija Kuzmanic,Marie Boutant,David Sala,Tuulia Hyötyläinen,Matej Orešič,Joana Fort,Joana Fort,Ekaitz Errasti-Murugarren,Cecília M. P. Rodrigues,Modesto Orozco,Jorge Joven,Carles Cantó,Manuel Palacín,Manuel Palacín,Sonia Fernández-Veledo,Joan Vendrell,Antonio Zorzano,Antonio Zorzano +38 more
TL;DR: It is demonstrated that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease and binds phosphatidylserine (PS) and can specifically extract PS into membrane domains, favoring PS transfer to mitochondria and mitochondrialosphatidylethanolamine (PE) synthesis.
Determination of ensemble-average pairwise root mean-square deviation from experimental B-factors.
Antonija Kuzmanic,Bojan Zagrovic +1 more
TL;DR: This work shows that the ensemble-average pairwise backbone RMSD for a microscopic ensemble underlying a typical protein x-ray structure is approximately 1.1 A, under the assumption that the principal contribution to experimental B-factors is conformational variability.
Journal ArticleDOI
X-ray refinement significantly underestimates the level of microscopic heterogeneity in biomolecular crystals
TL;DR: This work employs molecular dynamics simulations to controllably manipulate microscopic heterogeneity of a crystal containing 216 copies of villin headpiece and finds that both isotropic and anisotropic refined B-factors often significantly deviate from their actual values known from simulation.
Journal ArticleDOI
Biomolecular simulations: From dynamics and mechanisms to computational assays of biological activity
David J. Huggins,David J. Huggins,Philip C. Biggin,Marc A. Dämgen,Jonathan W. Essex,Sarah A. Harris,Richard H. Henchman,Syma Khalid,Antonija Kuzmanic,Charles A. Laughton,Julien Michel,Adrian J. Mulholland,Edina Rosta,Mark S.P. Sansom,Marc W. van der Kamp +14 more
TL;DR: In this review, biomolecular simulation methods are outlined and examples of its application to investigate questions in biology are highlighted, aiming to connect chemical and molecular changes to macroscopic observables.