D
David T. Evans
Researcher at University of Wisconsin-Madison
Publications - 97
Citations - 8213
David T. Evans is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Simian immunodeficiency virus & MHC class I. The author has an hindex of 37, co-authored 89 publications receiving 7554 citations. Previous affiliations of David T. Evans include Harvard University.
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Journal ArticleDOI
Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial
Barton F. Haynes,Peter B. Gilbert,M. Juliana McElrath,Susan Zolla-Pazner,Georgia D. Tomaras,S. Munir Alam,David T. Evans,David C. Montefiori,Chitraporn Karnasuta,Ruengpueng Sutthent,Hua-Xin Liao,Anthony L. DeVico,George K. Lewis,Constance Williams,Abraham Pinter,Youyi Fong,Holly Janes,Allan C. deCamp,Yunda Huang,Mangala Rao,Erik Billings,Nicos Karasavvas,Merlin L. Robb,Viseth Ngauy,Mark de Souza,Robert Paris,Guido Ferrari,Robert T. Bailer,Kelly A. Soderberg,Charla Andrews,Phillip W. Berman,Nicole Frahm,Stephen C. De Rosa,Michael D. Alpert,Nicole L. Yates,Xiaoying Shen,Richard A. Koup,Punnee Pitisuttithum,Jaranit Kaewkungwal,Sorachai Nitayaphan,Supachai Rerks-Ngarm,Nelson L. Michael,Jerome H. Kim +42 more
TL;DR: V vaccines that are designed to induce higher levels of V1V2 antibodies and lower levels of Env-specific IgA antibodies than are induced by the RV144 vaccine may have improved efficacy against HIV-1 infection.
Journal ArticleDOI
Apoptosis: a mechanism of cell killing by influenza A and B viruses.
TL;DR: These studies indicate that influenza A and B viruses induce apoptosis in cell cultures; thus, apoptosis may represent a general mechanism of cell death in hosts infected with influenza viruses.
Journal ArticleDOI
Reversion of CTL escape-variant immunodeficiency viruses in vivo.
Thomas C. Friedrich,Elizabeth J. Dodds,Levi Yant,Lara Vojnov,Richard Rudersdorf,Candice Cullen,David T. Evans,Ronald C. Desrosiers,Bianca R. Mothé,John Sidney,Alessandro Sette,Kevin J. Kunstman,Steven M. Wolinsky,Michael Piatak,Jeffrey D. Lifson,Austin L. Hughes,Nancy A. Wilson,David H. O’Connor,David I. Watkins +18 more
TL;DR: It is concluded that escape from CTL responses may exact a cost to viral fitness, and in the absence of selective pressure upon transmission to new hosts, these original escape mutations can be lost.
Journal ArticleDOI
Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef.
David T. Evans,David T. Evans,David H. O’Connor,Peicheng Jing,John L. Dzuris,John Sidney,Jack da Silva,Todd M. Allen,Helen Horton,John E. Venham,Richard Rudersdorf,Thorsten U. Vogel,C. David Pauza,Ronald E. Bontrop,Robert DeMars,Alessandro Sette,Austin L. Hughes,David I. Watkins +17 more
TL;DR: Ten CTL epitopes during the course of simian immunodeficiency virus disease progression in three related macaques showed evidence of positive selection by the time the macaques died, and these findings strongly support the CTL 'escape' hypothesis.
Journal ArticleDOI
Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination
Nicole L. Yates,Nicole L. Yates,Hua-Xin Liao,Hua-Xin Liao,Youyi Fong,Allan C. deCamp,Nathan Vandergrift,Nathan Vandergrift,William T. Williams,William T. Williams,S. Munir Alam,S. Munir Alam,Guido Ferrari,Guido Ferrari,Zhi Yong Yang,Kelly E. Seaton,Kelly E. Seaton,Phillip W. Berman,Michael D. Alpert,David T. Evans,Robert J. O'Connell,Donald P. Francis,Faruk Sinangil,Carter Lee,Sorachai Nitayaphan,Supachai Rerks-Ngarm,Jaranit Kaewkungwal,Punnee Pitisuttithum,James Tartaglia,Abraham Pinter,Susan Zolla-Pazner,Peter B. Gilbert,Gary J. Nabel,Nelson L. Michael,Jerome H. Kim,David C. Montefiori,David C. Montefiori,Barton F. Haynes,Barton F. Haynes,Georgia D. Tomaras +39 more
TL;DR: HIV-1–specific IgG3 responses were not long-lived, which was consistent with the waning efficacy of the RV144 vaccine, and should be evaluated in future HIV-1 vaccine efficacy trials to further refine immune correlates of protection.