D
Debashish Das
Researcher at University of Oxford
Publications - 30
Citations - 5372
Debashish Das is an academic researcher from University of Oxford. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 10, co-authored 16 publications receiving 4768 citations. Previous affiliations of Debashish Das include Médecins Sans Frontières & Mahidol University.
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Journal ArticleDOI
Artemisinin Resistance in Plasmodium falciparum Malaria
Arjen M. Dondorp,François Nosten,Poravuth Yi,Debashish Das,Aung Phae Phyo,Joel Tarning,Khin Maung Lwin,Frédéric Ariey,Warunee Hanpithakpong,Sue J. Lee,Pascal Ringwald,Kamolrat Silamut,Mallika Imwong,Kesinee Chotivanich,Pharath Lim,Trent Herdman,Sen Sam An,Shunmay Yeung,Pratap Singhasivanon,Nicholas P. J. Day,Niklas Lindegardh,Duong Socheat,Nicholas J. White +22 more
TL;DR: The overall median clearance times were 84 hours (interquartile range, 60 to 96) in Pailin and 48 hours in Wang Pha (P<0.001) in each of the two locations as discussed by the authors.
Journal ArticleDOI
Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
Elizabeth A. Ashley,Mehul Dhorda,Rick M. Fairhurst,Chanaki Amaratunga,Pharath Lim,Seila Suon,Sokunthea Sreng,Jennifer M. Anderson,Mao S,Sam B,Chantha Sopha,Char Meng Chuor,Chea Nguon,Siv Sovannaroth,Sasithon Pukrittayakamee,Podjanee Jittamala,Kesinee Chotivanich,K Chutasmit,C Suchatsoonthorn,R Runcharoen,Tran Tinh Hien,Nguyen Thuy-Nhien,Thanh Nv,Nguyen Hoan Phu,Ye Htut,Han Kt,Kyin Hla Aye,Olugbenga A. Mokuolu,Rasaq Olaosebikan,Olaleke Oluwasegun Folaranmi,Mayfong Mayxay,Maniphone Khanthavong,Bouasy Hongvanthong,Paul N. Newton,M A Onyamboko,Caterina I. Fanello,Antoinette Tshefu,Neelima Mishra,Neena Valecha,Aung Pyae Phyo,François Nosten,Yi P,Rupam Tripura,Steffen Borrmann,Mahfudh Bashraheil,Judy Peshu,M A Faiz,Aniruddha Ghose,M A Hossain,Rasheda Samad,M. R. Rahman,Manal Hasan,Ashraful Islam,Olivo Miotto,Roberto Amato,Bronwyn MacInnis,Jim Stalker,Dominic P. Kwiatkowski,Zbynek Bozdech,Atthanee Jeeyapant,Phaik Yeong Cheah,Tharisara Sakulthaew,Jeremy Chalk,Benjamas Intharabut,Kamolrat Silamut,Lee Sj,Benchawan Vihokhern,Chanon Kunasol,Mallika Imwong,Joel Tarning,Taylor Wj,Shunmay Yeung,Charles J. Woodrow,Jennifer A. Flegg,Debashish Das,Jennifer L. Smith,Meera Venkatesan,Christopher V. Plowe,Kasia Stepniewska,Philippe J Guerin,Arjen M. Dondorp,Nicholas P. J. Day,Nicholas J. White +82 more
TL;DR: Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing, and the incidence of pretreatment and post-treatment gametocytemia was higher among patients with slow parasite clearance, suggesting greater potential for transmission.
Journal ArticleDOI
High Heritability of Malaria Parasite Clearance Rate Indicates a Genetic Basis for Artemisinin Resistance in Western Cambodia
Tim J. Anderson,Shalini Nair,Standwell Nkhoma,Jeff T. Williams,Mallika Imwong,Poravuth Yi,Duong Socheat,Debashish Das,Kesinee Chotivanich,Nicholas P. J. Day,Nicholas J. White,Arjen M. Dondorp +11 more
TL;DR: A substantial proportion of the variation in clearance rate is explained by parasite genetics, which has 2 important implications: (1) selection with artemisinin derivatives will tend to drive resistance spread and (2) because heritability is high, the genes underlying parasite clearance rate may be identified by genome-wide association.
Journal ArticleDOI
Exploring the Contribution of Candidate Genes to Artemisinin Resistance in Plasmodium falciparum
Mallika Imwong,Arjen M. Dondorp,Arjen M. Dondorp,François Nosten,François Nosten,Poravuth Yi,Mathirut Mungthin,Sarun Hanchana,Debashish Das,Aung Phae Phyo,Khin Maung Lwin,Sasithon Pukrittayakamee,Sue J. Lee,Suwannee Saisung,Kitti Koecharoen,Chea Nguon,Nicholas P. J. Day,Nicholas P. J. Day,Duong Socheat,Nicholas J. White,Nicholas J. White +20 more
TL;DR: The reduced in vivo sensitivity of Plasmodium falciparum has recently been confirmed in western Cambodia as mentioned in this paper, and the artemisinin-resistant phenotype did not correlate with pfmdr1 amplification or mutations, mutations in pfATPase6 (full-length sequencing), or the 6-kb mitochondrial genome, or ubp-1 mutations at positions 739 and 770.
Journal ArticleDOI
Effect of High-Dose or Split-Dose Artesunate on Parasite Clearance in Artemisinin-Resistant Falciparum Malaria
Debashish Das,Rupam Tripura,Aung Pyae Phyo,Khin Maung Lwin,Joel Tarning,Joel Tarning,Sue J. Lee,Sue J. Lee,Warunee Hanpithakpong,Kasia Stepniewska,Didier Menard,Pascal Ringwald,Kamolrat Silamut,Mallika Imwong,Kesinee Chotivanich,Poravuth Yi,Nicholas P. J. Day,Nicholas P. J. Day,Niklas Lindegardh,Niklas Lindegardh,Duong Socheat,Chea Nguon,Nicholas J. White,Nicholas J. White,François Nosten,François Nosten,Arjen M. Dondorp,Arjen M. Dondorp +27 more
TL;DR: This randomized trial shows that neither increasing nor splitting the standard once-daily artesunate dose reverses the markedly reduced parasite clearance rate in patients with artemisinin-resistant falciparum malaria.