Debashish Das

TL;DR: The overall median clearance times were 84 hours (interquartile range, 60 to 96) in Pailin and 48 hours in Wang Pha (P<0.001) in each of the two locations as discussed by the authors.

TL;DR: Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing, and the incidence of pretreatment and post-treatment gametocytemia was higher among patients with slow parasite clearance, suggesting greater potential for transmission.

TL;DR: A substantial proportion of the variation in clearance rate is explained by parasite genetics, which has 2 important implications: (1) selection with artemisinin derivatives will tend to drive resistance spread and (2) because heritability is high, the genes underlying parasite clearance rate may be identified by genome-wide association.

TL;DR: The reduced in vivo sensitivity of Plasmodium falciparum has recently been confirmed in western Cambodia as mentioned in this paper, and the artemisinin-resistant phenotype did not correlate with pfmdr1 amplification or mutations, mutations in pfATPase6 (full-length sequencing), or the 6-kb mitochondrial genome, or ubp-1 mutations at positions 739 and 770.

TL;DR: This randomized trial shows that neither increasing nor splitting the standard once-daily artesunate dose reverses the markedly reduced parasite clearance rate in patients with artemisinin-resistant falciparum malaria.