D
Deepak Ramanujam
Researcher at Technische Universität München
Publications - 28
Citations - 1329
Deepak Ramanujam is an academic researcher from Technische Universität München. The author has contributed to research in topics: Myocyte & Medicine. The author has an hindex of 13, co-authored 18 publications receiving 844 citations.
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Journal ArticleDOI
MiR-378 Controls Cardiac Hypertrophy by Combined Repression of Mitogen-Activated Protein Kinase Pathway Factors
Jayavarshni Ganesan,Deepak Ramanujam,Yassine Sassi,Andrea Ahles,Claudia Jentzsch,Stanislas Werfel,Simon Leierseder,Xavier Loyer,Mauro Giacca,Lorena Zentilin,Thomas Thum,Bernhard Laggerbauer,Stefan Engelhardt +12 more
TL;DR: In this paper, microRNAs (miRs) have been shown to regulate gene expression in the heart and dysregulation of their expression has been linked to cardiac disease, and miR-378 was found to be both necessary and sufficient to repress cardiomyocyte hypertrophy.
Journal ArticleDOI
Essential Role for Premature Senescence of Myofibroblasts in Myocardial Fibrosis.
TL;DR: The data establish premature senescence of myofibroblasts as an essential antifibrotic mechanism and potential therapeutic target in myocardial fibrosis.
Journal ArticleDOI
H19 Induces Abdominal Aortic Aneurysm Development and Progression
Daniel Y. Li,Albert Busch,Hong Jin,Ekaterina Chernogubova,Jaroslav Pelisek,Joakim Karlsson,Bengt Sennblad,Shengliang Liu,Shen Lao,Patrick Hofmann,Alexandra Bäcklund,Suzanne M Eken,Joy Roy,Per Eriksson,Brian Dacken,Deepak Ramanujam,Anne Dueck,Stefan Engelhardt,Reinier A. Boon,Hans-Henning Eckstein,Joshua M. Spin,Philip S. Tsao,Lars Maegdefessel,Lars Maegdefessel +23 more
TL;DR: The long noncoding RNA H19 is a novel regulator of SMC survival in abdominal aortic aneurysm development and progression and might serve as a novel molecular therapeutic target for aorticsm disease.
Journal ArticleDOI
Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling.
Yassine Sassi,Yassine Sassi,Petros Avramopoulos,Deepak Ramanujam,Laurenz Grüter,Stanislas Werfel,Simon Giosele,Andreas-David Brunner,Dena Esfandyari,Aikaterini S. Papadopoulou,Aikaterini S. Papadopoulou,Bart De Strooper,Bart De Strooper,Norbert Hubner,Norbert Hubner,Regalla Kumarswamy,Thomas Thum,Xiaoke Yin,Manuel Mayr,Bernhard Laggerbauer,Stefan Engelhardt +20 more
TL;DR: It is shown that microRNA-29 can also enhance fibrotic signalling and pathological hypertrophy of the heart through its action in cardiomyocytes and cell- or tissue-specific antimiR-29 delivery may have therapeutic value for pathological cardiac remodeling and fibrosis.
Journal ArticleDOI
Critical Role for Stromal Interaction Molecule 1 in Cardiac Hypertrophy
Jean-Sébastien Hulot,Jérémy Fauconnier,Deepak Ramanujam,Antoine H. Chaanine,Fleur Cohen Aubart,Yassine Sassi,Sabine Merkle,Olivier Cazorla,Aude Ouillé,Morgan Dupuis,Lahouaria Hadri,Dongtak Jeong,Silke Mühlstedt,Joachim P. Schmitt,Attila Braun,Ludovic Benard,Youakim Saliba,Bernhard Laggerbauer,Bernhard Nieswandt,Alain Lacampagne,Roger J. Hajjar,Anne-Marie Lompré,Stefan Engelhardt +22 more
TL;DR: STIM1 is found to be both sufficient and necessary for cardiomyocyte hypertrophy in vitro and in the adult heart in vivo and controls a previously unrecognized sarcolemmal current, STIM1 promotes cardiachypertrophy.