D
Denise M. Monack
Researcher at Stanford University
Publications - 152
Citations - 24804
Denise M. Monack is an academic researcher from Stanford University. The author has contributed to research in topics: Innate immune system & Inflammasome. The author has an hindex of 73, co-authored 145 publications receiving 22245 citations. Previous affiliations of Denise M. Monack include Rocky Mountain Laboratories & University of California, Los Angeles.
Papers
More filters
Journal ArticleDOI
Cryopyrin activates the inflammasome in response to toxins and ATP
Sanjeev Mariathasan,David S. Weiss,Kim Newton,Jacqueline McBride,Karen O'Rourke,Meron Roose-Girma,Wyne P. Lee,Yvette Weinrauch,Denise M. Monack,Vishva M. Dixit +9 more
TL;DR: It is shown that cryopyrin-deficient macrophages cannot activate caspase-1 in response to Toll-like receptor agonists plus ATP, the latter activating the P2X7 receptor to decrease intracellular K+ levels.
Journal ArticleDOI
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf.
Sanjeev Mariathasan,Kim Newton,Denise M. Monack,Domagoj Vucic,Dorothy French,Wyne P. Lee,Meron Roose-Girma,Sharon Erickson,Vishva M. Dixit +8 more
TL;DR: Interestingly, cell death triggered by stimuli that engage caspase-1 was ablated in macrophages lacking either ASC or Ipaf, suggesting a coupling between the inflammatory and cell death pathways.
Journal ArticleDOI
Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation.
TL;DR: It is shown that the inflammasome is a dynamic entity that is assembled from different adaptors in a stimulus-dependent manner in response to various bacterial pathogens and tissue damage.
Journal ArticleDOI
Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens
Katharine M. Ng,Jessica A. Ferreyra,Steven K. Higginbottom,Jonathan B. Lynch,Purna C. Kashyap,Purna C. Kashyap,Smita Gopinath,Natasha Naidu,Biswa Choudhury,Bart C. Weimer,Denise M. Monack,Justin L. Sonnenburg +11 more
TL;DR: The data show that antibiotic-induced disruption of the resident microbiota and subsequent alteration in mucosal carbohydrate availability are exploited by these two distantly related enteric pathogens in a similar manner, which suggests new therapeutic approaches for preventing diseases caused by antibiotic-associated pathogens.
Journal ArticleDOI
The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1
TL;DR: The data demonstrate that SipB functions as an analog of the Shigella invasin IpaB, and functional inhibition of caspase-1 activity by acetyl-Tyr-Val-Ala-Asp-chloromethyl ketone blocks macrophage cytotoxicity, and macrophages lacking casp enzyme are not susceptible to Salmonella-induced apoptosis.