D
Donna G. Blackmond
Researcher at Scripps Health
Publications - 218
Citations - 13584
Donna G. Blackmond is an academic researcher from Scripps Health. The author has contributed to research in topics: Catalysis & Homochirality. The author has an hindex of 62, co-authored 210 publications receiving 12046 citations. Previous affiliations of Donna G. Blackmond include Scripps Research Institute & Max Planck Society.
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Journal ArticleDOI
Innate C-H trifluoromethylation of heterocycles.
Yining Ji,Tobias Brueckl,Ryan D. Baxter,Yuta Fujiwara,Ian B. Seiple,Shun Su,Donna G. Blackmond,Phil S. Baran +7 more
TL;DR: Preliminary data suggest that the regioselectivity of C-H trifluoromethylation can be fine-tuned simply by judicious solvent choice.
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Reaction progress kinetic analysis: a powerful methodology for mechanistic studies of complex catalytic reactions.
TL;DR: Reaction progress kinetic analysis to obtain a comprehensive picture of complex catalytic reaction behavior is described to help describe the driving forces of a reaction and may be used to help distinguish between different proposed mechanistic models.
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A New Reagent for Direct Difluoromethylation
Yuta Fujiwara,Janice A. Dixon,Rodrigo A. Rodriguez,Ryan D. Baxter,Darryl D. Dixon,Michael R. Collins,Donna G. Blackmond,Phil S. Baran +7 more
TL;DR: This mild, operationally simple, chemoselective, and scalable difluoromethylation method is compatible with a range of nitrogen-containing heteroarene substrates of varying complexity as well as select classes of conjugated π-systems and thiols.
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Emergence of a single solid chiral state from a nearly racemic amino acid derivative.
Wim L. Noorduin,Toshiko Izumi,Alessia Millemaggi,Michel Leeman,Hugo Meekes,Willem J. P. van Enckevort,Richard M. Kellogg,Bernard Kaptein,Elias Vlieg,Donna G. Blackmond +9 more
TL;DR: Attrition-enhanced dissolution and recrystallization processes based on solubility considerations of the Gibbs−Thomson rule, coupled with solution-phase racemization, drive this near-equilibrium system inexorably to single chirality in the solid phase.
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Mechanistic investigation leads to a synthetic improvement in the hydrolytic kinetic resolution of terminal epoxides.
TL;DR: The mechanism of the hydrolytic kinetic resolution (HKR) of terminal epoxides was investigated by kinetic analysis using reaction calorimetry and insight led to the identification of more active catalysts for the HKR of synthetically useful terminalEpoxides.