E
E. Israel
Researcher at Harvard University
Publications - 13
Citations - 903
E. Israel is an academic researcher from Harvard University. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 9, co-authored 13 publications receiving 869 citations.
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Journal ArticleDOI
Beyond Mortality: Future Clinical Research in Acute Lung Injury
Roger G. Spragg,Gordon R. Bernard,William Checkley,J. Randall Curtis,Ognjen Gajic,Gordon H. Guyatt,Jesse B. Hall,E. Israel,Manu Jain,Dale M. Needham,Adrienne G. Randolph,Gordon D. Rubenfeld,David A. Schoenfeld,B. Taylor Thompson,Lorraine B. Ware,Duncan Young,Andrea L. Harabin +16 more
TL;DR: The workshop assessed the current state of clinical research addressing ALI, identified research needs, and recommended: continued performance of trials evaluating treatments of patients with ALI; development of strategies to perform ALI prevention trials; and development of a standardized format for reporting methods, endpoints, and results of ALI trials.
Journal ArticleDOI
Systemic effect comparisons of six inhaled corticosteroid preparations
Richard J. Martin,Stanley J. Szefler,Vernon M. Chinchilli,Monica Kraft,Myrna Dolovich,Homer A. Boushey,Reuben M. Cherniack,Timothy J. Craig,Jeffrey M. Drazen,Joanne K. Fagan,John V. Fahy,James E. Fish,Jean G. Ford,E. Israel,Susan J. Kunselman,Stephen C. Lazarus,Robert F. Lemanske,Stephen P. Peters,Christine A. Sorkness +18 more
TL;DR: The goal of this study was to establish a reliable method to evaluate systemic bioavailability and to determine equisystemic effects (microgram dose producing equal systemic cortisol suppression) of inhaled corticosteroids (ICS) and to represent the first step in evaluation of ICS efficacy based on equis systemic effects of a given ICS.
Journal ArticleDOI
Amplification of airway constriction due to liquid filling of airway interstices.
TL;DR: A theoretical treatment of these two mechanisms together with data suggest that both may significantly amplify the luminal narrowing due to airway smooth muscle contraction, particularly in small airways when gamma is high.
Journal ArticleDOI
HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults.
Jessica Lasky-Su,Blanca E. Himes,Benjamin A. Raby,Barbara J. Klanderman,J. Senter Sylvia,Christoph Lange,Erik Melén,Erik Melén,Fernando D. Martinez,E. Israel,Jim Gauderman,Frank D. Gilliland,Patrick M. A. Sleiman,Hakon Hakonarson,Juan C. Celedón,Manuel E. Soto-Quiros,Lydiana Avila,John J. Lima,Charles G. Irvin,Stephen P. Peters,Homer A. Boushey,Vernon M. Chinchilli,David T. Mauger,Kelan G. Tantisira,Scott T. Weiss +24 more
TL;DR: This work has shown that an important genetic component to asthma susceptibility has long been recognized, most recently through the identification of several genes via genome‐wide association studies.
Journal ArticleDOI
Effect of chronic 5-lipoxygenase inhibition on airway hyperresponsiveness in asthmatic subjects.
TL;DR: Chronic zileuton treatment decreased airway hyperresponsiveness as determined by reactivity to cold, dry air.(ABSTRACT TRUNCATED AT 250 WORDS)