E
Edson X. Albuquerque
Researcher at University of Maryland, Baltimore
Publications - 268
Citations - 18565
Edson X. Albuquerque is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Nicotinic agonist & Acetylcholine. The author has an hindex of 69, co-authored 268 publications receiving 17395 citations. Previous affiliations of Edson X. Albuquerque include Federal University of Rio de Janeiro & National Institute on Drug Abuse.
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Journal ArticleDOI
Nanomolar concentrations of lead inhibit glutamatergic and GABAergic transmission in hippocampal neurons
TL;DR: It is most likely that the neurotoxic effects of Pb2+ in the mammalian brain involve a decrease of the TTX-sensitive, Ca2+-dependent release of neurotransmitters.
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Modulation of nicotinic receptor activity in the central nervous system: a novel approach to the treatment of Alzheimer disease.
TL;DR: Galantamine has been shown to improve cognitive and daily function for at least 6 months in placebo-controlled trials, and to maintain these functions at baseline levels at least 12 months in a 6-month open-label extension study as discussed by the authors.
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Ineffectiveness of enzyme therapy on regeneration in the transected spinal cord of the rat
Lloyd Guth,Edson X. Albuquerque,S.S. Deshpande,Charles P. Barrett,Edward J. Donati,Jordan E. Warnick +5 more
TL;DR: Transection of the spinal cord was performed in additional animals using Matinian and Andreasian's original surgical procedure and there were no significant behavioral, histological, or electrophysiological differences between any of the treatment groups.
Journal Article
Sites of action of phencyclidine. II. Interaction with the ionic channel of the nicotinic receptor.
Edson X. Albuquerque,Ming-Cheng Tsai,Robert S. Aronstam,Amira T. Eldefrawi,Mohyee E. Eldefrawi +4 more
TL;DR: PCP depressed peak EPC amplitude more markedly than it shortened the EPC decay time constant, thus disclosing that the depression of the former cannot be accounted for totally by the action of the agent on the open conformation of the ionic channel.
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[3H]Phencyclidine: a probe for the ionic channel of the nicotinic receptor.
Mohyee E. Eldefrawi,Amira T. Eldefrawi,Robert S. Aronstam,M. A. Maleque,J. E. Warnick,Edson X. Albuquerque +5 more
TL;DR: [3H]PCP depressed the peak amplitude of endplate current, caused nonlinearity in the voltage-current relationship at negative potentials, accelerated the decay time of the end-plateCurrent, and shortened the channel lifetime; there were a few differences between its effect and that of PCP.