E
Edson X. Albuquerque
Researcher at University of Maryland, Baltimore
Publications - 268
Citations - 18565
Edson X. Albuquerque is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Nicotinic agonist & Acetylcholine. The author has an hindex of 69, co-authored 268 publications receiving 17395 citations. Previous affiliations of Edson X. Albuquerque include Federal University of Rio de Janeiro & National Institute on Drug Abuse.
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Journal ArticleDOI
Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms.
Richard D. Burke,Spencer W. Todd,Eric W. Lumsden,Roger J. Mullins,Jacek Mamczarz,William P. Fawcett,Rao P. Gullapalli,William R. Randall,Edna F. R. Pereira,Edson X. Albuquerque +9 more
TL;DR: The primary objectives of this article are to address the short‐ and long‐term neurological issues that have been associated with acute and subacute exposures of humans to OP insecticides, especially early in life, and to discuss the translational relevance of animal models of developmental exposure to OP Insecticides.
Journal ArticleDOI
Nicotinic Receptor Function in the Mammalian Central Nervous Systema
Edson X. Albuquerque,Edson X. Albuquerque,Edna F. R. Pereira,Edna F. R. Pereira,Newton G. Castro,Newton G. Castro,Manickavasagom Alkondon,Sigrid Reinhardt,Hannsjörg Schröder,Alfred Maelicke +9 more
TL;DR: The findings can be summarized as follows: hippocampal neurons express at least three subtypes of CNS nAChRs, and there is an ACh-insensitive site on neuronal and nonneuronal nA ChRs through which the receptor channel can be activated.
Journal ArticleDOI
Methyllycaconitine and (+)-anatoxin-a differentiate between nicotinic receptors in vertebrate and invertebrate nervous systems
David R. E. Macallan,George G. Lunt,Susan Wonnacott,K L Swanson,Henry Rapoport,Edson X. Albuquerque +5 more
TL;DR: The data suggest that (+)‐anatoxin‐a is a useful probe for the high‐affinity nicotine‐binding receptor in vertebrate brain, whereas MLA is a preferential probe for a subclass of receptor that binds α‐bungarotoxin.
Journal ArticleDOI
Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents
Edson X. Albuquerque,Edna F. R. Pereira,Yasco Aracava,William P. Fawcett,Maristela Oliveira,William R. Randall,Tracey A. Hamilton,Robert K. Kan,James A. Romano,Michael Adler +9 more
TL;DR: It is demonstrated that galantamine, a reversible and centrally acting AChE inhibitor approved for treatment of mild to moderate Alzheimer’s disease, protects guinea pigs from the acute toxicity of lethal doses of the nerve agents soman and sarin, and of paraoxon, the active metabolite of the insecticide parathion.
Journal ArticleDOI
Galantamine is an allosterically potentiating ligand of the human alpha4/beta2 nAChR.
Marek Samochocki,Marion Zerlin,Ruth Jostock,P. J. Groot Kormelink,Walter Luyten,Edson X. Albuquerque,Alfred Maelicke,Alfred Maelicke +7 more
TL;DR: The same action of galantamine is demonstrated on the most abundant nAChR in the human brain, the α4/β2 subtype, as is shown by the absence of this effect for other therapeutically applied AChE inhibitors including tacrine, metrifonate, rivastigmine and donepezil.