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Edson X. Albuquerque

Researcher at University of Maryland, Baltimore

Publications -  268
Citations -  18565

Edson X. Albuquerque is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Nicotinic agonist & Acetylcholine. The author has an hindex of 69, co-authored 268 publications receiving 17395 citations. Previous affiliations of Edson X. Albuquerque include Federal University of Rio de Janeiro & National Institute on Drug Abuse.

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Batrachotoxinin-A 20-alpha-benzoate: a new radioactive ligand for voltage sensitive sodium channels.

TL;DR: The data support the conclusion that BTX-B interacts with a recognition site associated with voltage sensitive sodium channels which is identical to the recognition site for BTX.
Journal Article

Mechanism of action of amantadine on neuromuscular transmission.

TL;DR: The effects of amantadine on postsynaptic ionic current, coupled with its inability to protect against blockade of transmission by α-bungarotoxin and its inhibition of [3H]perhydrohistrionicotoxin binding suggest that amantdine blocks neuromuscular transmission by reacting with the ionic channel of the acetylcholine receptor.
Journal ArticleDOI

Expression of functional alpha7 nicotinic acetylcholine receptor during mammalian muscle development and denervation.

TL;DR: The highest level of expression was observed in the first postnatal week, when practically all muscle cells stained positively for α7 protein, and during the following weeks, α7 nAChR expression slowly decreased and practically disappeared in adult hindleg muscle.
Journal Article

Sites of action of phencyclidine. III. Interactions with muscarinic receptors.

TL;DR: PCP and PCP-MeI are considered antagonists of muscarmnic receptors in rat brain because of their inhibition of the contractions of longitudinal muscle of guinea pig ileum and specific binding of [3H]QNB to muscarinic receptors in these muscles and rat brain.
Journal Article

Alpha-conotoxin-ImI: a competitive antagonist at alpha-bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons.

TL;DR: The competitive and reversible nature of the alpha-conotoxin-ImI-induced inhibition of native alpha 7-bearing neuronal nicotinic receptors makes this peptide a valuable new tool for the functional and structural characterization of these receptors in the central nervous system.