E
Edson X. Albuquerque
Researcher at University of Maryland, Baltimore
Publications - 268
Citations - 18565
Edson X. Albuquerque is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Nicotinic agonist & Acetylcholine. The author has an hindex of 69, co-authored 268 publications receiving 17395 citations. Previous affiliations of Edson X. Albuquerque include Federal University of Rio de Janeiro & National Institute on Drug Abuse.
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Journal Article
Human vascular endothelial cells express functional nicotinic acetylcholine receptors
Kevin D. Macklin,Arno D. J. Maus,Edna F. R. Pereira,Edson X. Albuquerque,Bianca M. Conti-Fine +4 more
TL;DR: It is demonstrated here that endothelial cells that line blood vessels express functional AChRs, similar to those of the nAChRs expressed by ganglionic neurons and by skin keratinocytes and bronchial epithelial cells.
Journal ArticleDOI
Human and Rodent Bronchial Epithelial Cells Express Functional Nicotinic Acetylcholine Receptors
Arno D. J. Maus,Edna F. R. Pereira,Peter I. Karachunski,Robert M. Horton,Duraiswamy Navaneetham,Kevin Macklin,Wellington da Silva Côrtes,Wellington da Silva Côrtes,Edson X. Albuquerque,Edson X. Albuquerque,Bianca M. Conti-Fine +10 more
TL;DR: It is demonstrated here that human and rodent bronchial epithelial cells (BECs) express AChRs similar to those expressed by keratinocytes and by some neurons, which may mediate or facilitate some of the toxic effects of cigarette smoking in the respiratory system.
Journal Article
Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting ligands.
André Schrattenholz,Edna F. R. Pereira,U. Roth,K.-H. Weber,Edson X. Albuquerque,Alfred Maelicke +5 more
TL;DR: The sensitizing actions of galanthamine, 5-hydroxytryptamine, and related compounds, at submicromolar concentrations, may reflect the existence of cross-talk between adjacent neuroreceptors and synapses in the central nervous system and thus suggests the formation of transiently active chemical networks in the vertebrate brain.
Journal ArticleDOI
Nicotinic Acetylcholine Receptor α7 and α4β2 Subtypes Differentially Control GABAergic Input to CA1 Neurons in Rat Hippocampus
TL;DR: The hippocampus, a limbic brain region involved in the encoding and retrieval of memory, has a well-defined structural network assembled from excitatory principal neurons and inhibitory interneuron...
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Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease.
TL;DR: A novel class of nicotinic acetylcholine receptor ligands which, similar to the action of benzodiazepines on GABA(A) receptors, allosterically potentiate submaximal Nicotinic responses are described, which could have a preventive and corrective action on impaired but still functioningNicotinic neurotransmission.