E
Edson X. Albuquerque
Researcher at University of Maryland, Baltimore
Publications - 268
Citations - 18565
Edson X. Albuquerque is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Nicotinic agonist & Acetylcholine. The author has an hindex of 69, co-authored 268 publications receiving 17395 citations. Previous affiliations of Edson X. Albuquerque include Federal University of Rio de Janeiro & National Institute on Drug Abuse.
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Journal Article
Properties of Neuronal Nicotinic Acetylcholine Receptors: Pharmacological Characterization and Modulation of Synaptic Function,
Edson X. Albuquerque,Manickavasagom Alkondon,Edna F. R. Pereira,Newton G. Castro,André Schrattenholz,Catão T. F. Barbosa,Rafael Bonfante-Cabarcas,Yasco Aracava,Howard M. Eisenberg,Alfred Maelicke +9 more
TL;DR: It is an honor to receive from the American Society of Pharmacology and Experimental Therapeutics the 1996 Otto Krayer Award sponsored by Zeneca Pharmaceutics Co.
Journal Article
Neuronal nicotinic acetylcholine receptor activation modulates gamma -aminobutyric acid release from ca1 neurons of rat hippocampal slices
TL;DR: In this paper, the authors investigated electrophysiologically the nicotinic responses of pyramidal neurons and interneurons visualized by infrared-assisted videomicroscopy and fluorescence in the CA1 field of hippocampal slices obtained from 8- to 24-day-old rats.
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Galantamine Is an Allosterically Potentiating Ligand of Neuronal Nicotinic but Not of Muscarinic Acetylcholine Receptors
Marek Samochocki,Anja Höffle,Andreas Fehrenbacher,Ruth Jostock,Jürgen Ludwig,Claudia Christner,Martin Radina,Marion Zerlin,Christoph Ullmer,Edna F. R. Pereira,Hermann Lübbert,Edson X. Albuquerque,Alfred Maelicke +12 more
TL;DR: These studies support the previous proposal that the therapeutic action of galantamine is mainly produced by its sensitizing action on nAChRs rather than by general cholinergic enhancement due to cholinesterase inhibition.
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α-Bungarotoxin-and methyllycaconitine-sensitive nicotinic receptors mediate fast synaptic transmission in interneurons of rat hippocampal slices
TL;DR: It is demonstrated for the first time that α7 nicotinic receptors (nAChRs) mediate fast synaptic transmission in conventional hippocampal slices and serves as an excitatory signal to the CA1 interneurons in the hippocampus.
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alpha-Bungarotoxin-sensitive hippocampal nicotinic receptor channel has a high calcium permeability.
TL;DR: The hippocampal nicotinic acetylcholine- and NMDA-activated whole-cell currents were determined and it was found that the neuronal alpha-BGT-sensitive nAChR is a cation channel considerably selective to Ca2+ and may mediate a fast rise in intracellular Ca2+.