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Edson X. Albuquerque

Researcher at University of Maryland, Baltimore

Publications -  268
Citations -  18565

Edson X. Albuquerque is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Nicotinic agonist & Acetylcholine. The author has an hindex of 69, co-authored 268 publications receiving 17395 citations. Previous affiliations of Edson X. Albuquerque include Federal University of Rio de Janeiro & National Institute on Drug Abuse.

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Journal ArticleDOI

Allosteric modulation of Torpedo nicotinic acetylcholine receptor ion channel activity by noncompetitive agonists.

Alfred Maelicke, +5 more
- 01 Jan 1997 - 
TL;DR: The action of a novel class of nAChR ligands which act as allosterically potentiating ligands (APL) on the nicotinic responses induced by ACh and competitive agonists are discussed.
Journal Article

Sites of action of phencyclidine. I. Effects on the electrical excitability and chemosensitive properties of the neuromuscular junction of skeletal muscle

Ming-Cheng Tsai, +5 more
- 01 Jan 1980 - 
TL;DR: The effects of phencyclidine (PCP) on the electrical and chemosensitive properties of the neuromuscular junction of skeletal muscles as well as on the binding of ligands to acetyicholine (ACh) receptors in the electric organ membranes of the electric ray were studied in this paper.
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Acute Toxicity of Organophosphorus Compounds in Guinea Pigs Is Sex- and Age-Dependent and Cannot Be Solely Accounted for by Acetylcholinesterase Inhibition

William P. Fawcett, +4 more
- 01 Feb 2009 - 
TL;DR: The results demonstrate for the first time that the lethal potencies of some nerve agents in guinea pigs are age- and sex-dependent and support the contention that mechanisms other than AChE inhibition contribute to the lethality of nerve agents.
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The demonstration of neurotrophic function by application of colchicine or vinblastine to the peripheral nerve.

J. E. Warnick, +2 more
- 01 Nov 1977 - 
TL;DR: Application of Silastic cuffs containing either colchicine or vinblastine to the sciatic nerves of rats produced electrophysiological signs of denervation without altering electrical activity along the nerve, spontaneous or evoked transmitter release, or the contractile activity of the muscles examined.
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Noncompetitive agonism at nicotinic acetylcholine receptors; functional significance for CNS signal transduction.

Alfred Maelicke, +9 more
- 01 Jan 1995 - 
TL;DR: In more general terms, noncompetitive agonists may constitute part of a "chemical network", by which intercellular messengers, in addition to serving their cognate receptors, could modulate the sensitivity of other neuroreceptors to their archetypic ligands.