E
Edwin H. Cook
Researcher at University of Illinois at Chicago
Publications - 339
Citations - 61045
Edwin H. Cook is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Autism & Heritability of autism. The author has an hindex of 102, co-authored 337 publications receiving 54518 citations. Previous affiliations of Edwin H. Cook include University of Chicago & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
A pharmacogenetic study of escitalopram in autism spectrum disorders
Thomas Owley,Camille W. Brune,Jeff Salt,Laura Walton,Steve Guter,Nelson Ayuyao,Robert D. Gibbons,Bennett L. Leventhal,Edwin H. Cook +8 more
TL;DR: This genotype‐blind, prospective pharmacogenetic study found the group of subjects with associated with the lowest platelet 5‐HT uptake from previous study had the smallest reduction in ABC‐Irritability scores after open label treatment with escitalopram.
Journal ArticleDOI
Relationship of EGFR Mutations, Expression, Amplification, and Polymorphisms to Epidermal Growth Factor Receptor Inhibitors in the NCI60 Cell Lines
Wanqing Liu,Xiaolin Wu,Wei Zhang,Raquel C. Montenegro,Donna Lee Fackenthal,Jared A Spitz,Lyn Mickley Huff,Federico Innocenti,Soma Das,Edwin H. Cook,Nancy J. Cox,Susan E. Bates,Mark J. Ratain +12 more
TL;DR: Observations suggest that in addition to TK mutations, germ-line variability may also contribute to the pharmacodynamics of EGFR inhibitors, particularly when EGFR is genetically normal.
Journal ArticleDOI
A framework for an evidence-based gene list relevant to autism spectrum disorder
Christian P. Schaaf,Christian P. Schaaf,Christian P. Schaaf,Catalina Betancur,Ryan K. C. Yuen,Ryan K. C. Yuen,Jeremy R. Parr,David Skuse,Louise Gallagher,Raphael Bernier,Raphael Bernier,Janet A. Buchanan,Joseph D. Buxbaum,Chun-An Chen,Kira A. Dies,Mayada Elsabbagh,Helen V. Firth,Thomas W. Frazier,Ny Hoang,Jennifer L. Howe,Christian R. Marshall,Jacques L. Michaud,Olivia Rennie,Peter Szatmari,Wendy K. Chung,Patrick Bolton,Edwin H. Cook,Stephen W. Scherer,Stephen W. Scherer,Jacob A. S. Vorstman,Jacob A. S. Vorstman +30 more
TL;DR: This Roadmap discusses important considerations necessary to provide an evidence-based framework for the curation of NDD genes based on the level of information supporting a clinically relevant relationship between a given gene and ASD.
Journal ArticleDOI
Interactions between early parenting and a polymorphism of the child's dopamine transporter gene in predicting future child conduct disorder symptoms.
Benjamin B. Lahey,Paul J. Rathouz,Steve S. Lee,Andrea Chronis-Tuscano,William E. Pelham,Irwin D. Waldman,Edwin H. Cook +6 more
TL;DR: There was a significant inverse relation between levels of both positive and negative parenting at 4-6 years and the number of later CD symptoms, but primarily among children with 2 copies of the 9-repeat allele of the VNTR.
Journal ArticleDOI
Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism.
Sarah N. Cross,Soo Jeong Kim,Soo Jeong Kim,Lauren A. Weiss,Lauren A. Weiss,Ryan J. Delahanty,James S. Sutcliffe,Bennett L. Leventhal,Edwin H. Cook,Jeremy Veenstra-VanderWeele,Jeremy Veenstra-VanderWeele +10 more
TL;DR: These initial studies of indices of the 5-HT system with several single-nucleotide polymorphisms at loci in this system generate hypotheses for testing in other samples.