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Edwin H. Cook
Researcher at University of Illinois at Chicago
Publications - 339
Citations - 61045
Edwin H. Cook is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Autism & Heritability of autism. The author has an hindex of 102, co-authored 337 publications receiving 54518 citations. Previous affiliations of Edwin H. Cook include University of Chicago & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Reduced behavioral flexibility in autism spectrum disorders
Anna Maria D'Cruz,Michael E. Ragozzino,Matthew W. Mosconi,Sunil Shrestha,Edwin H. Cook,John A. Sweeney +5 more
TL;DR: Restricted and repetitive behaviors in ASD are associated with neurocognitive deficits in flexible choice behavior, and alterations in frontostriatal circuitry may contribute to behavioral rigidity in ASD and represent a target for therapeutic intervention.
Journal ArticleDOI
Cytogenetic and molecular characterization of A2BP1/FOX1 as a candidate gene for autism.
Christa Lese Martin,Jacqueline A. Duvall,Yesim Ilkin,Jason S. Simon,M. Gladys Arreaza,Kristin Wilkes,Ana Isabel Alvarez-Retuerto,Amy Whichello,Cynthia M. Powell,Kathleen W. Rao,Edwin H. Cook,Daniel H. Geschwind +11 more
TL;DR: A de novo translocation between the short arms of chromosomes 15 and 16 in a female with autism, epilepsy, and global developmental delay is reported, suggesting that A2BP1 may affect susceptibility or cause autism in a subset of patients.
Journal ArticleDOI
Linkage Disequilibrium of the Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Children With a Prepubertal and Early Adolescent Bipolar Disorder Phenotype
Barbara Geller,Judith A. Badner,Rebecca Tillman,Susan L. Christian,Kristine Bolhofner,Edwin H. Cook +5 more
TL;DR: This finding in child bipolar disorder is consistent with data for adults with bipolar disorder that show preferential transmission of the Val66 allele.
Journal ArticleDOI
Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability.
Abdul Noor,Annabel Whibley,Christian R. Marshall,Peter J. Gianakopoulos,Amélie Piton,Andrew R. Carson,M Orlic-Milacic,Anath C. Lionel,Daisuke Sato,Dalila Pinto,Irene Drmic,Carolyn Noakes,Lili Senman,Xiaoyun Zhang,Rong Mo,Julie Gauthier,Jennifer Crosbie,Alistair T. Pagnamenta,Jeffrey Munson,Annette Estes,Andreas Fiebig,Andre Franke,Stefan Schreiber,Alexandre F.R. Stewart,Robert Roberts,Ruth McPherson,Stephen J. Guter,Edwin H. Cook,Geraldine Dawson,Gerard D. Schellenberg,Agatino Battaglia,Elena Maestrini,Linda Jeng,Terry Hutchison,Evica Rajcan-Separovic,Albert E. Chudley,Suzanne M E Lewis,Xudong Liu,Jeanette J. A. Holden,Bridget A. Fernandez,Lonnie Zwaigenbaum,Susan E. Bryson,Wendy Roberts,Peter Szatmari,Louise Gallagher,Michael R. Stratton,Jozef Gecz,Angela F. Brady,Charles E. Schwartz,Russell Schachar,Anthony P. Monaco,Guy A. Rouleau,Chi-chung Hui,F. Lucy Raymond,Stephen W. Scherer,John B. Vincent +55 more
TL;DR: Genetic analysis in thousands of patients and control subjects suggests that the PTCHD1 gene may be part of the Hedgehog signaling pathway, which is important in embryonic development, and suggests that this locus is involved in ~1% of individuals with ASD and intellectual disability.
Journal ArticleDOI
Ancestry and pharmacogenetics of antileukemic drug toxicity.
Shinji Kishi,Cheng Cheng,Deborah L. French,Deqing Pei,Soma Das,Edwin H. Cook,Nobuko Hijiya,Nobuko Hijiya,Carmelo Rizzari,Gary L. Rosner,Tony N. Frudakis,Ching-Hon Pui,Ching-Hon Pui,William E. Evans,William E. Evans,Mary V. Relling,Mary V. Relling +16 more
TL;DR: The genotype-phenotype associations were similar whether analyses were adjusted by self-reported race or ancestry-informative genetic markers, and Germ-line polymorphisms are significant determinants of toxicity of antileukemic therapy.