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Elaine R. Levy
Researcher at Wellcome Trust Centre for Human Genetics
Publications - 37
Citations - 2577
Elaine R. Levy is an academic researcher from Wellcome Trust Centre for Human Genetics. The author has contributed to research in topics: Locus (genetics) & Gene mapping. The author has an hindex of 25, co-authored 37 publications receiving 2511 citations. Previous affiliations of Elaine R. Levy include University of Oxford.
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Journal ArticleDOI
Localization of the X inactivation centre on the human X chromosome in Xq13
Carolyn J. Brown,Ronald G. Lafreniere,Vicki E. Powers,Gianfranco Sebastio,Andrea Ballabio,Anjana L. Pettigrew,David H. Ledbetter,Elaine R. Levy,Ian W. Craig,Huntington F. Willard +9 more
TL;DR: An analysis of several rearranged human X chromosomes is reported and a minimal region of overlap is defined that is consistent with models invoking a single XIC and provide a molecular foothold for cloning and analysing the XIC region.
Journal ArticleDOI
Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family.
S D Brown,Rebecca C.J. Twells,Patricia J. Hey,Roger D. Cox,Elaine R. Levy,A. R. Soderman,Michael L. Metzker,C. T. Caskey,John A. Todd,J F Hess +9 more
TL;DR: The cytoplasmic domain of LRP6 is not similar to other members of the LDLR family, while comparison with LRP5 reveals proline-rich motifs that may mediate protein-protein interactions, likely to comprise a new class of the HDLR family.
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The SPCH1 region on human 7q31: genomic characterization of the critical interval and localization of translocations associated with speech and language disorder.
Cecilia S. L. Lai,Simon E. Fisher,Jane A. Hurst,Elaine R. Levy,Shirley Hodgson,Margaret Fox,Stephen Jeremiah,Susan Povey,D. Curtis Jamison,Eric D. Green,Faraneh Vargha-Khadem,Anthony P. Monaco +11 more
TL;DR: A detailed BAC-/PAC-based sequence map of this interval is assembled, containing 152 sequence tagged sites (STSs), 20 known genes, and >7.75 Mb of completed genomic sequence in the KE family, and refinement of the SPCH1 interval to a region between new markers 013A and 330B is refined.
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Spermatogenic failure in male mice lacking H-Y antigen.
TL;DR: It is shown that H–Y-negative male mice, in losing the genetic information that encodes H-Y, have also lost genetic information required for spermatogenesis, and this result identifies a gene on the mouse Y,inct from the testis-determining gene, which is necessary for sarcolysis, and raises the intriguing possibility that the product of this ‘spermatogenic gene’ is H–y antigen.
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A 2-Mb YAC Contig and Physical Map of the Natural Killer Gene Complex on Mouse Chromosome 6 ☆
Michael G. Brown,Michael G. Brown,Susanna Fulmek,Keiko Matsumoto,Robert Cho,Paul A. Lyons,Elaine R. Levy,Anthony A. Scalzo,Wayne M. Yokoyama,Wayne M. Yokoyama +9 more
TL;DR: It is shown that Nkrp1 genes are clustered in a region flanked by A2m and Cd69 genes and that most Ly49 genes are clusters in a distal region -1 Mb distant, and syntenic intervals of mouse chromosome 6 and human chromosome 12p that include the NKC are conserved.