J
J F Hess
Researcher at United States Military Academy
Publications - 4
Citations - 2505
J F Hess is an academic researcher from United States Military Academy. The author has contributed to research in topics: Gene & Gene mapping. The author has an hindex of 4, co-authored 4 publications receiving 2422 citations.
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Journal ArticleDOI
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
H Ueda,Howson Jmm.,Laura Esposito,Joanne M. Heward,Hywel Snook,Giselle Chamberlain,Dan Rainbow,Hunter Kmd.,Anne Smith,G Di Genova,G Di Genova,Mathias H. Herr,Mathias H. Herr,Ingrid Dahlman,Ingrid Dahlman,F Payne,Deborah J. Smyth,Christopher E. Lowe,Twells Rcj.,Sarah Howlett,Barry C. Healy,Sarah Nutland,Helen E. Rance,Vincent H. Everett,Luc J. Smink,A C Lam,Heather J. Cordell,Neil Walker,C Bordin,John S. Hulme,Costantino Motzo,Francesco Cucca,J F Hess,Michael L. Metzker,Michael L. Metzker,Jane Rogers,Simon G. Gregory,Amit Allahabadia,Amit Allahabadia,R Nithiyananthan,Eva Tuomilehto-Wolf,Jaakko Tuomilehto,Polly J. Bingley,Kathleen M Gillespie,Dag E. Undlien,Kjersti S. Rønningen,Cristian Guja,Constantin Ionescu-Tirgoviste,David A. Savage,Alexander P. Maxwell,Dennis Carson,Christopher Patterson,Jayne A. Franklyn,David Clayton,Laurence B. Peterson,Linda S. Wicker,John A. Todd,Gough Scl. +57 more
TL;DR: In this article, the authors identify polymorphisms of the cytotoxic T lymphocyte antigen 4 gene (CTLA4) as candidates for primary determinants of risk of the common autoimmune disorders Graves' disease, autoimmune hypothyroidism and type 1 diabetes.
Journal ArticleDOI
Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family.
S D Brown,Rebecca C.J. Twells,Patricia J. Hey,Roger D. Cox,Elaine R. Levy,A. R. Soderman,Michael L. Metzker,C. T. Caskey,John A. Todd,J F Hess +9 more
TL;DR: The cytoplasmic domain of LRP6 is not similar to other members of the LDLR family, while comparison with LRP5 reveals proline-rich motifs that may mediate protein-protein interactions, likely to comprise a new class of the HDLR family.
Journal ArticleDOI
Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes.
D J Figueroa,J F Hess,Bonnie Ky,S D Brown,V Sandig,A Hermanowski-Vosatka,Rebecca C.J. Twells,John A. Todd,Christopher P. Austin +8 more
TL;DR: An extensive expression analysis of this gene at the mRNA and protein levels in normal human, monkey, and mouse, as well as in non-obese diabetic (NOD) mice, suggests that LRP5 may confer Type 1 diabetes risk by altering the normal functioning of one or more of these regulatory systems.
Journal ArticleDOI
The Sequence and Gene Characterization of a 400-kb Candidate Region for IDDM4 on Chromosome 11q13 ☆
Rebecca C.J. Twells,Michael L. Metzker,S D Brown,Roger D. Cox,C Garey,Holly A. Hammond,Patricia J. Hey,Elaine R. Levy,Y Nakagawa,M S Philips,John A. Todd,J F Hess +11 more
TL;DR: Detailed sequence analysis has identified three genes in a 400-kb region of the IDDM4 region that have similarity to the SIT4 (sporulation-induced transcript 4)-associated protein (SAP) family of yeast proteins, which are involved in regulation of the cell cycle and the first mammalian orthologue of the yeast SAP family to be identified.