Elizabeth A. Maher

TL;DR: It is demonstrated that cancer cells containing amplifications surrounding the MCL1 and BCL2L1 anti-apoptotic genes depend on the expression of these genes for survival, and a large majority of SCNAs identified in individual cancer types are present in several cancer types.

TL;DR: Although a comprehensive view of the genetic lesions encountered in malignant gliomas has been compiled, substantive conceptual and practical barriers remain in assigning functional significance to these genetic changes and in harnessing this basic information into the development of drugs that make a difference in patient care.

TL;DR: These data support the view that dysregulation of specific genetic pathways, rather than cell-of-origin, dictates the emergence and phenotype of high-grade gliomas and provide evidence that p16(INK4a) and p19(ARF) synergize to maintain terminal astrocyte differentiation.

TL;DR: In this article, a non-invasive detection of 2-hydroxyglutarate (2HG) by proton magnetic resonance spectroscopy (MRS) was reported.

TL;DR: The data demonstrate a strikingly common metabolic phenotype in diverse brain tumors that includes the ability to oxidize acetate in the citric acid cycle, which may be important for meeting the high biosynthetic and bioenergetic demands of malignant growth.