Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.
Robert M. Bachoo,Elizabeth A. Maher,Keith L. Ligon,Norman E. Sharpless,Suzanne S Chan,Mingjian James You,Yi Tang,Jessica DeFrances,Elizabeth H. Stover,Ralph Weissleder,David H. Rowitch,David N. Louis,Ronald A. DePinho +12 more
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TLDR
These data support the view that dysregulation of specific genetic pathways, rather than cell-of-origin, dictates the emergence and phenotype of high-grade gliomas and provide evidence that p16(INK4a) and p19(ARF) synergize to maintain terminal astrocyte differentiation.About:
This article is published in Cancer Cell.The article was published on 2002-04-01 and is currently open access. It has received 682 citations till now. The article focuses on the topics: Astrocyte differentiation & Neural stem cell.read more
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Identification of human brain tumour initiating cells
Sheila K. Singh,Cynthia Hawkins,Ian D. Clarke,Jeremy A. Squire,Jane Bayani,Takuichiro Hide,R. Mark Henkelman,Michael D. Cusimano,Peter B. Dirks +8 more
TL;DR: The development of a xenograft assay that identified human brain tumour initiating cells that initiate tumours in vivo gives strong support for the CSC hypothesis as the basis for many solid tumours, and establishes a previously unidentified cellular target for more effective cancer therapies.
Journal Article
Identification of a Cancer Stem Cell in Human Brain Tumors
Sheila K. Singh,Ian D. Clarke,Mizuhiko Terasaki,Victoria E. Bonn,Cynthia Hawkins,Jeremy A. Squire,Peter B. Dirks +6 more
TL;DR: The identification and purification of a cancer stem cell from human brain tumors of different phenotypes that possesses a marked capacity for proliferation, self-renewal, and differentiation is reported.
Journal ArticleDOI
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
Heidi S. Phillips,Samir Kharbanda,Ruihuan Chen,William F. Forrest,Robert Soriano,Thomas D. Wu,Anjan Misra,Janice Nigro,Howard Colman,Liliana Soroceanu,P. Mickey Williams,Zora Modrusan,Burt G. Feuerstein,Kenneth Aldape +13 more
TL;DR: Previously undescribed prognostic subclasses of high-grade astrocytoma are identified and discovered to resemble stages in neurogenesis, suggesting functional relevance of tumor subtype molecular signatures is suggested by the ability of cell line signatures to predict neurosphere growth.
Journal ArticleDOI
Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma
Rossella Galli,Elena Binda,Ugo Orfanelli,Barbara Cipelletti,Angela Gritti,Simona De Vitis,Roberta Fiocco,Chiara Foroni,Francesco DiMeco,Angelo L. Vescovi +9 more
TL;DR: It is reported that, unlike other brain cancers, the lethal glioblastoma multiforme contains neural precursors endowed with all of the critical features expected from neural stem cells.
Journal ArticleDOI
Malignant astrocytic glioma: genetics, biology, and paths to treatment.
Frank B. Furnari,Tim R. Fenton,Robert M. Bachoo,Akitake Mukasa,Jayne M. Stommel,Alexander H. Stegh,William C. Hahn,Keith L. Ligon,David N. Louis,Cameron Brennan,Lynda Chin,Ronald A. DePinho,Webster K. Cavenee +12 more
TL;DR: The recent confluence of advances in stem cell biology, cell signaling, genome and computational science and genetic model systems have revolutionized understanding of the mechanisms underlying the genetics, biology and clinical behavior of glioblastoma.
References
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Book
The Mouse Brain in Stereotaxic Coordinates
TL;DR: The 3rd edition of this atlas is now in more practical 14"x11" format for convenient lab use and includes a CD of all plates and diagrams, as well as Adobe Illustrator files of the diagrams, and a variety of additional useful material.
Journal ArticleDOI
Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
Brent A. Reynolds,Samuel Weiss +1 more
TL;DR: Cells of the adult mouse striatum have the capacity to divide and differentiate into neurons and astrocytes.
Journal ArticleDOI
Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain
Fiona Doetsch,Isabelle Caillé,Daniel A. Lim,José Manuel García-Verdugo,Arturo Alvarez-Buylla +4 more
TL;DR: It is shown that SVZ astrocytes act as neural stem cells in both the normal and regenerating brain and give rise to cells that grow into multipotent neurospheres in vitro.
Journal ArticleDOI
Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.
K. D. McCarthy,J. de Vellis +1 more
TL;DR: These preparations should significantly aid in efforts to examine the biochemistry, physiology, and pharmacology of these two major classes of central nervous system cells.
Journal ArticleDOI
Role of the INK4a locus in tumor suppression and cell mortality
TL;DR: It is demonstrated that the INK4a locus functions to suppress neoplastic growth and the introduction of activated Ha-ras into INk4a-deficient fibroblasts can result in neoplastics transformation.
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