R
Robert W. Wysocki
Researcher at Rush University Medical Center
Publications - 144
Citations - 9320
Robert W. Wysocki is an academic researcher from Rush University Medical Center. The author has contributed to research in topics: Saccharomyces cerevisiae & Elbow. The author has an hindex of 32, co-authored 129 publications receiving 8306 citations. Previous affiliations of Robert W. Wysocki include Rush University & University of Wrocław.
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Journal ArticleDOI
Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis
Elizabeth A. Winzeler,Daniel D. Shoemaker,Anna Astromoff,Hong Liang,Keith Anderson,Bruno André,Rhonda Bangham,Rocío Benito,Jef D. Boeke,Howard Bussey,Angela M. Chu,Carla Connelly,Karen Davis,Fred S. Dietrich,Sally Dow,Mohamed El Bakkoury,Françoise Foury,Stephen H. Friend,Erik Gentalen,Guri Giaever,Johannes H. Hegemann,Ted Jones,Michael T. Laub,Hong Liao,Nicole Liebundguth,David J. Lockhart,Anca Lucau-Danila,Marc Lussier,Nasiha M'Rabet,Patrice Menard,Michael Mittmann,Chai Pai,Corinne Rebischung,José L. Revuelta,Linda Riles,Christopher J. Roberts,Petra Ross-Macdonald,Bart Scherens,Michael Snyder,Sharon Sookhai-Mahadeo,Reginald Storms,Steeve Veronneau,Marleen Voet,Guido Volckaert,Teresa R. Ward,Robert W. Wysocki,Grace Yen,Kexin Yu,Katja Zimmermann,Peter Philippsen,Mark Johnston,Ronald W. Davis +51 more
TL;DR: A total of 6925 Saccharomyces cerevisiae strains were constructed, by a high-throughput strategy, each with a precise deletion of one of 2026 ORFs (more than one-third of the ORFs in the genome), finding that 17 percent were essential for viability in rich medium.
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Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps
Juwon Park,Robert W. Wysocki,Robert W. Wysocki,Zohreh Amoozgar,Laura Maiorino,Laura Maiorino,Miriam R. Fein,Miriam R. Fein,Julie M. Jorns,Anne F. Schott,Yumi Kinugasa-Katayama,Youngseok Lee,Nam Hee Won,Elizabeth S. Nakasone,Elizabeth S. Nakasone,Stephen Hearn,Victoria Küttner,Jing Qiu,Ana S. Almeida,Naiara Perurena,Kai Kessenbrock,Michael S. Goldberg,Mikala Egeblad +22 more
TL;DR: The data suggest that induction of NETs by cancer cells is a previously unidentified metastasis-promoting tumor-host interaction and a potential therapeutic target, and treatment with NET-digesting, DNase I–coated nanoparticles markedly reduced lung metastases in mice.
Journal ArticleDOI
The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae
Robert W. Wysocki,Cyrille C. Chéry,Donata Wawrzycka,Marijn Van Hulle,Rita Cornelis,Johan M. Thevelein,Markus J. Tamás +6 more
TL;DR: It is shown by direct transport assays that arsenite uptake is mediated by Fps1p, and the first report describing a eukaryotic uptake mechanism for arsenite and antimonite and its involvement in metalloid tolerance is described.
Journal ArticleDOI
Role of Dot1-Dependent Histone H3 Methylation in G1 and S Phase DNA Damage Checkpoint Functions of Rad9
TL;DR: A key role for chromatin and methylation of histone H3 Lys 79 in yeast DNA damage signaling is indicated andscreened radiation-sensitive yeast mutants for DNA damage checkpoint defects and identified Dot1, the conserved hist one H 3 Lys 79 methyltransferase.
Journal ArticleDOI
Molecular profiling of activated neurons by phosphorylated ribosome capture.
Zachary A. Knight,Keith Tan,Kıvanç Birsoy,Sarah F Schmidt,Jennifer L. Garrison,Robert W. Wysocki,Ana Emiliano,Mats I. Ekstrand,Jeffrey M. Friedman +8 more
TL;DR: It is shown that ribosomal protein S6, a structural component of the ribosome, becomes phosphorylated in neurons activated by a wide range of stimuli and can be captured from mouse brain homogenates, thereby enriching directly for the mRNAs expressed in discrete subpopulations of activated cells.