Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug
Eloise Mastrangelo,Margherita Pezzullo,Tine De Burghgraeve,Suzanne J.F. Kaptein,Boris Pastorino,Kai Dallmeier,Xavier de Lamballerie,Johan Neyts,Alicia M. Hanson,David N. Frick,Martino Bolognesi,Mario Milani +11 more
TLDR
Ivermectin, a broadly used anti-helminthic drug, proved to be a highly potent inhibitor of YFV replication and inhibited, although less efficiently, the replication of several other flaviviruses, i.e. dengue fever, Japanese encephalitis and tick-borne encephalopathy viruses.Abstract:
Objectives
Infection with yellow fever virus (YFV), the prototypic mosquito-borne flavivirus, causes severe febrile disease with haemorrhage, multi-organ failure and a high mortality. Moreover, in recent years the Flavivirus genus has gained further attention due to re-emergence and increasing incidence of West Nile, dengue and Japanese encephalitis viruses. Potent and safe antivirals are urgently needed.read more
Citations
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The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro.
TL;DR: Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum anti-viral activity in vitro, is an inhibitor of the causative virus (SARS-CoV-2), with a single addition to Vero-hSLAM cells 2 h post infection able to effect ~5000-fold reduction in viral RNA at 48 h.
Journal ArticleDOI
An Update on Current Therapeutic Drugs Treating COVID-19.
Renyi Wu,Lujing Wang,Hsiao-Chen Dina Kuo,Ahmad Shannar,Rebecca Peter,Pochung Jordan Chou,Shanyi Li,Rasika Hudlikar,Xia Liu,Xia Liu,Zhigang Liu,George J. Poiani,George J. Poiani,Louis F. Amorosa,Luigi Brunetti,Luigi Brunetti,Ah-Ng Tony Kong +16 more
TL;DR: It is hoped that this review will provide useful and most updated therapeutic drugs to prevent, control, and treat COVID-19 patients until the approval of vaccines and specific drugs targeting SARS-CoV-2.
Journal ArticleDOI
A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection
Nicholas J. Barrows,Nicholas J. Barrows,Rafael K. Campos,Rafael K. Campos,Steven T. Powell,K. Reddisiva Prasanth,Geraldine Schott-Lerner,Ruben Soto-Acosta,Gaddiel Galarza-Muñoz,Erica L. McGrath,Rheanna Urrabaz-Garza,Junling Gao,Ping Wu,Ramkumar Menon,George R. Saade,Ildefonso Fernández-Salas,Shannan L. Rossi,Nikos Vasilakis,Andrew Routh,Shelton S. Bradrick,Mariano A. Garcia-Blanco,Mariano A. Garcia-Blanco +21 more
TL;DR: A library of FDA-approved drugs was interrogated for their ability to block infection of human HuH-7 cells by a newly isolated ZIKV strain (ZIKV MEX_I_7) and established anti-flaviviral drugs and others that had no previously known antiviral activity were identified as inhibitors of ZikV infection.
Journal ArticleDOI
Virtual screening for potential inhibitors of human hexokinase II for the development of anti-dengue therapeutics
TL;DR: Novel compounds are proposed, which may act as potential drugs against DENV by inhibiting HKII’s activity by using the computational studies.
Journal ArticleDOI
Ten years of dengue drug discovery: Progress and prospects
Siew Pheng Lim,Qing Yin Wang,Christian G. Noble,Yen Liang Chen,Hongping Dong,Bin Zou,Fumiaki Yokokawa,Shahul Nilar,Paul Smith,David Beer,Julien Lescar,Pei Yong Shi +11 more
TL;DR: The knowledge accumulated during the past decade has provided a better rationale for ongoing dengue drug discovery and it is optimistic that this continuous, concerted effort will lead to an effective d Dengue therapy.
References
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