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Enza Vernucci
Researcher at Eppley Institute for Research in Cancer and Allied Diseases
Publications - 24
Citations - 1286
Enza Vernucci is an academic researcher from Eppley Institute for Research in Cancer and Allied Diseases. The author has contributed to research in topics: Pancreatic cancer & Cancer cell. The author has an hindex of 14, co-authored 23 publications receiving 831 citations. Previous affiliations of Enza Vernucci include Sapienza University of Rome & Open University.
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Journal ArticleDOI
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.
Surendra K. Shukla,Vinee Purohit,Kamiya Mehla,Venugopal Gunda,Nina V. Chaika,Enza Vernucci,Ryan J. King,Jaime Abrego,Gennifer D. Goode,Aneesha Dasgupta,Alysha L. Illies,Teklab Gebregiworgis,Bingbing Dai,Jithesh J. Augustine,Divya Murthy,Kuldeep S. Attri,Oksana Mashadova,Paul M. Grandgenett,Robert Powers,Quan P. Ly,Audrey J. Lazenby,Jean L. Grem,Fang Yu,José M. Matés,John M. Asara,Jung Whan Kim,Jordan Hankins,Colin D. Weekes,Michael A. Hollingsworth,Natalie J. Serkova,Aaron R. Sasson,Jason B. Fleming,Jennifer M. Oliveto,Costas A. Lyssiotis,Lewis C. Cantley,Lyudmyla Berim,Pankaj K. Singh,Pankaj K. Singh +37 more
TL;DR: A widely prevalent mechanism of resistance to gemcitabine in pancreatic cancer is established, whereby increased glycolytic flux leads to glucose addiction in cancer cells and a corresponding increase in pyrimidine biosynthesis to enhance the intrinsic levels of deoxycytidine triphosphate (dCTP).
Journal ArticleDOI
SIRT5 regulation of ammonia-induced autophagy and mitophagy
Lucia Polletta,Enza Vernucci,Ilaria Carnevale,Tania Arcangeli,Dante Rotili,Silvia Palmerio,Clemens Steegborn,Theresa Nowak,Mike Schutkowski,Laura Pellegrini,Luigi Sansone,Lidia Villanova,Alessandra Runci,Bruna Pucci,Emanuela Morgante,Massimo Fini,Antonello Mai,Matteo Antonio Russo,Marco Tafani +18 more
TL;DR: The role of SIRT5 in nonliver cells is to regulate ammonia production and ammonia-induced autophagy by regulating glutamine metabolism.
Journal ArticleDOI
De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer.
Saber Tadros,Surendra K. Shukla,Ryan J. King,Venugopal Gunda,Enza Vernucci,Jaime Abrego,Nina V. Chaika,Fang Yu,Audrey J. Lazenby,Lyudmyla Berim,Jean L. Grem,Aaron R. Sasson,Pankaj K. Singh +12 more
TL;DR: It is demonstrated that fatty acid biosynthesis pathway manipulation can help overcome the gemcitabine resistance in pancreatic cancer by regulating ER stress and stemness.
Journal ArticleDOI
Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth
Surendra K. Shukla,Aneesha Dasgupta,Kamiya Mehla,Venugopal Gunda,Enza Vernucci,Joshua J. Souchek,Gennifer D. Goode,Ryan King,Anusha Mishra,Ibha Rai,Sangeetha Nagarajan,Nina V. Chaika,Fang Yu,Pankaj K. Singh +13 more
TL;DR: In conclusion, silibinin-induced metabolic reprogramming diminishes cell growth and cachectic properties of pancreatic cancer cells and animal models.
Journal ArticleDOI
GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells.
Jaime Abrego,Venugopal Gunda,Enza Vernucci,Surendra K. Shukla,Ryan J. King,Aneesha Dasgupta,Gennifer D. Goode,Divya Murthy,Fang Yu,Pankaj K. Singh +9 more
TL;DR: The studies suggest that targeting anaplerotic glutamine metabolism may serve as an important therapeutic target in PDAC and suggest that GOT1 plays an important role in energy metabolism and ROS balance in chronic acidosis stress.