E
Enzo Z. Poirier
Researcher at Francis Crick Institute
Publications - 6
Citations - 216
Enzo Z. Poirier is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Innate immune system & Viral replication. The author has an hindex of 3, co-authored 6 publications receiving 68 citations.
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Journal ArticleDOI
Slicing and dicing viruses: antiviral RNA interference in mammals
TL;DR: Cellular and viral factors that impact on antiviral RNAi are discussed and the contexts in which this system might be at play in mammalian resistance to viral infection are discussed.
Journal ArticleDOI
An isoform of Dicer protects mammalian stem cells against multiple RNA viruses.
Enzo Z. Poirier,Michael D. Buck,Probir Chakravarty,Joana Carvalho,Bruno Frederico,Ana Cardoso,Lyn Healy,Rachel Ulferts,Rupert Beale,Rupert Beale,Caetano Reis e Sousa +10 more
TL;DR: In this paper, the authors identified an isoform of Dicer, named antiviral Dicer (aviD), that protects tissue stem cells from RNA viruses by dicing viral double-stranded RNA to orchestrate antiviral RNAi.
Journal ArticleDOI
Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity
Evangelos Giampazolias,Oliver Schulz,Kok Haw Jonathan Lim,Neil C. Rogers,Probir Chakravarty,Naren Srinivasan,Oliver Gordon,Ana Cardoso,Michael D. Buck,Enzo Z. Poirier,Johnathan Canton,Santiago Zelenay,Stefano Sammicheli,Natalia Moncaut,Sunita Varsani-Brown,Ian Rosewell,Caetano Reis e Sousa +16 more
TL;DR: In this article, secreted gelsolin (sGSN), an extracellular protein, decreases DNGR-1 binding to F-actin and cross-presentation of dead cell-associated antigens by cDC1s.
Posted ContentDOI
Standard operating procedures for SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay
Michael D. Buck,Enzo Z. Poirier,Ana Cardoso,Bruno Frederico,Johnathan Canton,Sam Barrell,Rupert Beale,Rupert Beale,Richard D. Byrne,Simon Caidan,Margaret Crawford,Laura Cubitt,Steve Gamblin,Sonia Gandhi,Sonia Gandhi,Sonia Gandhi,Robert J. Goldstone,Paul Grant,Kiran Gulati,Steve Hindmarsh,Michael Howell,Mike Hubank,Mike Hubank,Rachael Instrell,Ming Jiang,George Kassiotis,Wei-Ting Lu,James I. MacRae,Iana Martini,Davin Miller,David Moore,David Moore,Eleni Nastouli,Eleni Nastouli,Jerome Nicod,Luke Nightingale,Jessica Olsen,Amin Oomatia,Nicola O’Reilly,Anett Rideg,Ok-Ryul Song,Amy Strange,Charles Swanton,Charles Swanton,Charles Swanton,Samra Turajlic,Samra Turajlic,Philip A. Walker,Mary Wu,Caetano Reis e Sousa +49 more
TL;DR: This work presents a clinically-validated standard operating procedure (SOP) for high-throughput SARS- CoV-2 detection by RT-LAMP in 25 minutes that is robust, reliable, repeatable, sensitive, specific, and inexpensive.
Journal ArticleDOI
SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay
Michael D. Buck,Enzo Z. Poirier,Ana Cardoso,Bruno Frederico,Johnathan Canton,Sam Barrell,Rupert Beale,Richard D. Byrne,Simon Caidan,Margaret Crawford,Laura Cubitt,Sonia Gandhi,Sonia Gandhi,Robert L. Goldstone,Paul Grant,Kiran Gulati,Steve Hindmarsh,Michael Howell,Mike Hubank,Mike Hubank,Rachael Instrell,Ming Jiang,George Kassiotis,Wei-Ting Lu,James I. MacRae,Iana Martini,Davin Miller,David Moore,Eleni Nastouli,Eleni Nastouli,Jerome Nicod,Luke Nightingale,Jessica Olsen,Amin Oomatia,Nicola O’Reilly,Anett Rideg,Ok-Ryul Song,Amy Strange,Charles Swanton,Charles Swanton,Samra Turajlic,Samra Turajlic,Mary Wu,Caetano Reis e Sousa +43 more
TL;DR: This work presents a clinically-validated procedure for high-throughput SARS-CoV-2 detection by RT-LAMP in 25 minutes that is robust, reliable, repeatable, sensitive, specific, and inexpensive.