Eric A. Lefevre

TL;DR: A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo, consistent with a role for BAFF in maintaining homeostasis of the B cell population.

TL;DR: Data suggest that restricted patterns of CCR6 expression and MIP-3alpha/CCL20 responsiveness are integral parts of the process of B-lineage maturation and antigen-driven B-cell differentiation.

TL;DR: It is shown that B cell Ag receptor (BCR) triggering, but not stimulation by CD40 mAb and/or IL-4, rapidly induced the coordinated expression of two closely related T cell chemoattractants, macrophage inflammatory protein-1 beta and MIP-1 alpha, by human B cells.

TL;DR: The findings indicate a previously unreported role for the BAFF/BAFF-R pair in mature B-cell chemotaxis and the synergy between CXCL13 and BAFF produced by stromal cells and follicular dendritic cells may have important implications for B- Cell homeostasis, the development of normal B- cell areas, and for the formation of germinal center-like follicles that may be observed in various autoimmune diseases.

TL;DR: CD4+ T-cell-independent antibody responses play a major role in the resolution of foot-and-mouth disease in cattle, and depletion was found to substantially inhibit antibody responses to the G-H peptide loop VP1135-156 on the viral capsid.