Baff Binds to the Tumor Necrosis Factor Receptor–Like Molecule B Cell Maturation Antigen and Is Important for Maintaining the Peripheral B Cell Population
Jeffrey Thompson,Pascal Schneider,Susan L. Kalled,Li Chun Wang,Eric A. Lefevre,Teresa G. Cachero,Fabienne Mackay,Sarah A. Bixler,Mohammad Zafari,Zhong-Ying Liu,Stephen A. Woodcock,Fang Qian,Marcel Batten,Christine Madry,Yolande Richard,Christopher D. Benjamin,Jeffrey L. Browning,Andreas Tsapis,Jürg Tschopp,Christine Ambrose +19 more
TLDR
A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo, consistent with a role for BAFF in maintaining homeostasis of the B cell population.Abstract:
The tumor necrosis factor (TNF) family member B cell activating factor (BAFF) binds B cells and enhances B cell receptor–triggered proliferation. We find that B cell maturation antigen (BCMA), a predicted member of the TNF receptor family expressed primarily in mature B cells, is a receptor for BAFF. Although BCMA was previously localized to the Golgi apparatus, BCMA was found to be expressed on the surface of transfected cells and tonsillar B cells. A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo. Moreover, culturing splenic cells in the presence of BAFF increased survival of a percentage of the B cells. These results are consistent with a role for BAFF in maintaining homeostasis of the B cell population.read more
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DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
Mikhail B. Litinskiy,Bernardetta Nardelli,David M. Hilbert,Bing He,András Schaffer,Paolo Casali,Andrea Cerutti +6 more
TL;DR: By eliciting CD40-independent Ig class switching and plasmacytoid differentiation, BLyS and APRIL critically link the innate and adaptive immune responses.
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BAFF AND APRIL: a tutorial on B cell survival.
TL;DR: The BAFF system provides not only potential insight into the development of autoreactive B cells but a relatively simple paradigm to begin considering the balancing act between survival, growth, and death that affects all cells.
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A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo.
Suping Li,Qiao Jiang,Shaoli Liu,Yinlong Zhang,Yanhua Tian,Yanhua Tian,Chen Song,Jing Wang,Yiguo Zou,Gregory J. Anderson,Jing Yan Han,Yung Chang,Yan Liu,Chen Zhang,Liang Chen,Guang-Biao Zhou,Guangjun Nie,Guangjun Nie,Hao Yan,Baoquan Ding,Yuliang Zhao,Yuliang Zhao +21 more
TL;DR: It is demonstrated that intravenously injected DNA nanorobots deliver thrombin specifically to tumor-associated blood vessels and induce intravascular thrombosis, resulting in tumor necrosis and inhibition of tumor growth.
Journal ArticleDOI
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren’s syndrome
Joanna R Groom,Susan L. Kalled,Anne H. Cutler,Carl Olson,Stephen A. Woodcock,Pascal Schneider,Jürg Tschopp,Teresa G. Cachero,Marcel Batten,Julie Wheway,Davide Mauri,Dana Cavill,Tom P. Gordon,Charles R. Mackay,Fabienne Mackay +14 more
TL;DR: It is demonstrated that BAFF Tg mice, as they age, develop a secondary pathology reminiscent of Sjögren's syndrome, and altered B cell differentiation and tolerance induced by excess BAFF may be central to SS pathogenesis.
Journal ArticleDOI
Elevated serum B lymphocyte stimulator levels in patients with systemic immune–based rheumatic diseases
TL;DR: BLyS may be an important factor in driving polyclonal hypergammaglobulinemia and elevated autoantibody titers in patients with systemic immune-based rheumatic diseases.
References
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Journal ArticleDOI
Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations.
Fabienne Mackay,Stephen A. Woodcock,Pornsri Lawton,Christine Ambrose,Manfred Baetscher,Pascal Schneider,Jürg Tschopp,Jeffrey L. Browning +7 more
TL;DR: Mice transgenic for BAFF have vastly increased numbers of mature B and effector T cells, and develop autoimmune-like manifestations such as the presence of high levels of rheumatoid factors, circulating immune complexes, anti–DNA autoantibodies, and immunoglobulin deposition in the kidneys.
Journal ArticleDOI
BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
Pascal Schneider,Fabienne Mackay,Véronique Steiner,Kay Hofmann,Jean Luc Bodmer,Nils Holler,Christine Ambrose,Pornsri Lawton,Sarah A. Bixler,Hans Acha-Orbea,Danila Valmori,Pedro Romero,Christiane Werner-Favre,Rudolph H. Zubler,Jeffrey L. Browning,Jürg Tschopp +15 more
TL;DR: A novel member of the T NF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells is described, suggesting that BAFF plays an important role as costimulator of B cell proliferation and function.
Journal ArticleDOI
TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
Jane A. Gross,Janet V. Johnston,Sherri Mudri,Rachel Enselman,Stacey R. Dillon,Karen L. Madden,Wenfeng Xu,Julia Parrish-Novak,Don Foster,Catherine Lofton-Day,Margaret D. Moore,Alisa Littau,Angelika Grossman,Harald S. Haugen,Kevin P. Foley,Hal Blumberg,Kim Harrison,Wayne R. Kindsvogel,Christopher H. Clegg +18 more
TL;DR: These findings demonstrate the involvement of zTNF4 and its receptors in the development of SLE and identify TACI–Ig as a promising treatment of autoimmune disease in humans.
Journal ArticleDOI
BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator
Paul A. Moore,Ornella Belvedere,Amy Orr,Krystyna Pieri,David W. Lafleur,Ping Feng,Daniel R. Soppet,Meghan Charters,Reiner L. Gentz,David Parmelee,Yuling Li,Olga Galperina,Judith Giri,Viktor Roschke,Bernardetta Nardelli,Jeffrey Carrell,Svetlana Sosnovtseva,Wilbert Greenfield,Steven M. Ruben,Henrik S. Olsen,James Fikes,David M. Hilbert +21 more
TL;DR: The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation, and its expression on human monocytes could be up-regulated by interferon-gamma.
Journal ArticleDOI
Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.
David Banner,Allan D'Arcy,Wolfgang Janes,Reiner L. Gentz,Hans-Joachim Schoenfeld,Clemens Broger,Hansruedi Loetscher,Werner Lesslauer +7 more
TL;DR: The X-ray crystal structure of the complex of the extracellular domain of the human 55 kd tumor necrosis factor (TNF) receptor with human TNF beta has been determined and is likely to be representative of the nerve growth factor (NGF)/TNF receptor family as a whole.
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