Ken Kosik

TL;DR: This work has localized the PS-1 gene to a 75 kb region and present the structure of this gene, evidence for alternative splicing and describe six novel mutations in early onset FAD pedigrees all of which alter residues conserved in the STM26 (Presenilin 2: PS-2) gene.

TL;DR: Clinical features of a very large pedigree with early-onset Alzheimer disease (AD) in which all affected individuals carry the identical glutamic acid-to-alanine mutation at codon 280 in the presenilin-1 gene are characterized, suggesting an important role for environmental factors or genetic modifiers in determining the age at onset.

TL;DR: It is concluded that CHIP, as a bimolecular switch, interacts with HSP to stabilize normal holo-betaAPP on the one hand while also assisting in the ubiquitination of a subpopulation of betaAPP molecules that are destined for proteasome degradation.

TL;DR: Eotaxin-1 appears to modify Alzheimer's AAO, conferring a large (~10 years) protective effect and open potential avenues for therapy.

TL;DR: A novel sequential strategy that combines pooling of DNA and bootstrapping (pbGWAS) in order to significantly increase the statistical power and exponentially reduce expenses is described, which could provide important insights in determining the genetic causes of AD and other complex conditions.