Virginia Buckles

TL;DR: In this paper, a longitudinal study of 128 patients with Alzheimer's disease was conducted, where the authors used the participant's age at baseline assessment and the parent's age to calculate the estimated years from expected symptom onset (age of the participant minus parent's ages at symptom onset).

TL;DR: Cognitive function in nondemented aging appears to be degraded by the presence of NFTs and SPs, and neuropathological processes related to AD in persons without dementia appear to be associated with subtle cognitive dysfunction and may represent a preclinical stage of the illness.

TL;DR: This work examined the severity and distribution of WMH in presymptomatic PSEN1, PSEN2, and APP mutation carriers to determine the extent to which WMH manifest in individuals genetically determined to develop AD.

TL;DR: Analysis of cerebrospinal fluid (CSF) collected longitudinally in research participants in the Dominantly Inherited Alzheimer Network (DIAN), a multicenter, international biomarker study of ADAD, revealed reductions in amyloid-β1–42 (indicating the presence ofAmyloid plaques) and increases in markers of neuronal injury (tau, ptau181, and VILIP-1) in mutation carriers during the early presymptomatic stage.

TL;DR: A pattern of tau staging is identified where site-specific phosphorylation changes occur at different periods of disease progression and follow distinct trajectories over time, providing insights into the pathways linking tau, amyloid-β and neurodegeneration in dominantly inherited Alzheimer's disease.