C
Christian Barro
Researcher at University Hospital of Basel
Publications - 82
Citations - 6811
Christian Barro is an academic researcher from University Hospital of Basel. The author has contributed to research in topics: Multiple sclerosis & Medicine. The author has an hindex of 29, co-authored 74 publications receiving 3966 citations. Previous affiliations of Christian Barro include University of Southern California & Harvard University.
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Journal ArticleDOI
Neurofilaments as biomarkers in neurological disorders
Michael Khalil,Charlotte E. Teunissen,Markus Otto,Fredrik Piehl,Maria Pia Sormani,Thomas Gattringer,Christian Barro,Ludwig Kappos,Manuel Comabella,Franz Fazekas,Axel Petzold,Kaj Blennow,Kaj Blennow,Henrik Zetterberg,Jens Kuhle +14 more
TL;DR: How technological advances have enabled the detection of neurofilament proteins in the blood is considered, and how these proteins consequently have the potential to be easily measured biomarkers of neuroaxonal injury in various neurological conditions are discussed.
Journal ArticleDOI
Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis.
Giulio Disanto,Christian Barro,Pascal Benkert,Yvonne Naegelin,Sabine Schädelin,Antonella Giardiello,Chiara Zecca,Kaj Blennow,Henrik Zetterberg,David Leppert,Ludwig Kappos,Claudio Gobbi,Jens Kuhle +12 more
TL;DR: The value of an ultrasensitive single‐molecule array (Simoa) serum NfL (sNfL) assay in multiple sclerosis (MS) is explored.
Journal ArticleDOI
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease
Oliver Preische,Oliver Preische,Stephanie A. Schultz,Anja Apel,Anja Apel,Jens Kuhle,Stephan A. Kaeser,Stephan A. Kaeser,Christian Barro,Susanne Gräber,Elke Kuder-Buletta,Christian LaFougere,Christoph Laske,Christoph Laske,Jonathan Vöglein,Jonathan Vöglein,Johannes Levin,Johannes Levin,Colin L. Masters,Ralph N. Martins,Peter R. Schofield,Peter R. Schofield,Martin N. Rossor,Neill R. Graff-Radford,Stephen Salloway,Bernardino Ghetti,John M. Ringman,James M. Noble,Jasmeer P. Chhatwal,Alison Goate,Tammie L.S. Benzinger,John C. Morris,Randall J. Bateman,Guoqiao Wang,Anne M. Fagan,Eric McDade,Brian A. Gordon,Mathias Jucker,Mathias Jucker +38 more
TL;DR: Serum NfL dynamics in serum predict disease progression and brain neurodegeneration at the early presymptomatic stages of familial Alzheimer’s disease, which supports its potential utility as a clinically useful biomarker.
Journal ArticleDOI
Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa
Jens Kuhle,Christian Barro,Ulf Andreasson,Tobias Derfuss,Raija L.P. Lindberg,Åsa Sandelius,Victor Liman,Niklas Norgren,Kaj Blennow,Henrik Zetterberg +9 more
TL;DR: The highly sensitive Simoa technology deserves further studies in larger patient cohorts to clarify whether serum NfL could be used in the future to measure disease severity and determine prognosis or response to treatment interventions in neurological diseases.
Journal ArticleDOI
Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis.
Christian Barro,Pascal Benkert,Giulio Disanto,Charidimos Tsagkas,Michael Amann,Yvonne Naegelin,David Leppert,Claudio Gobbi,Cristina Granziera,Özgür Yaldizli,Zuzanna Michalak,Jens Wuerfel,Ludwig Kappos,Katrin Parmar,Jens Kuhle +14 more
TL;DR: Serum neurofilament light chain levels are a real-time, easy to measure marker of neuro-axonal injury that is conceptually more comprehensive than brain MRI and correlated with concurrent and future clinical and MRI measures of disease activity and severity.