Open AccessJournal Article
Clinical and biomarker changes in dominantly inherited alzheimer's disease
Peter R. Schofield,Randall J. Bateman,Chengjie Xiong,Tls Benzinger,Anne M. Fagan,Alison Goate,Nick C. Fox,Daniel S. Marcus,Nigel J. Cairns,X Xie,Tyler Blazey,David M. Holtzman,Anna Santacruz,Virginia Buckles,Angela Oliver,Krista L. Moulder,Paul S. Aisen,Bernardino Ghetti,William E. Klunk,Eric McDade,Ralph N. Martins,Colin L. Masters,Richard Mayeux,John M. Ringman,Martin N. Rossor,Reisa A. Sperling,Stephen Salloway,John C. Morris +27 more
TLDR
It is found that autosomal dominant Alzheimer's disease was associated with a series of pathophysiological changes over decades in CSF biochemical markers of Alzheimer’s disease, brain amyloid deposition, and brain metabolism as well as progressive cognitive impairment.About:
This article is published in Clinical and Experimental Pharmacology and Physiology.The article was published on 2013-10-01 and is currently open access. It has received 642 citations till now. The article focuses on the topics: Biomarker (medicine).read more
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Journal ArticleDOI
The amyloid hypothesis of Alzheimer's disease at 25 years
Dennis J. Selkoe,John Hardy +1 more
TL;DR: In a recent study, this article showed that low cerebrospinal fluid (CSF) Aβ42 and amyloid-PET positivity precede other AD manifestations by many years.
Journal ArticleDOI
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
Bruno Dubois,Bruno Dubois,Howard Feldman,Claudia Jacova,Harald Hampel,Harald Hampel,José Luis Molinuevo,Kaj Blennow,Steven T. DeKosky,Serge Gauthier,Dennis J. Selkoe,Randall J. Bateman,Stefano F. Cappa,Sebastian J. Crutch,Sebastiaan Engelborghs,Giovanni B. Frisoni,Nick C. Fox,Douglas Galasko,Marie-Odile Habert,Gregory A. Jicha,Agneta Nordberg,Florence Pasquier,Gil D. Rabinovici,Philippe Robert,Christopher C. Rowe,Stephen Salloway,Marie Sarazin,Stéphane Epelbaum,Stéphane Epelbaum,Leonardo Cruz de Souza,Leonardo Cruz de Souza,Leonardo Cruz de Souza,Bruno Vellas,Pieter Jelle Visser,Lon S. Schneider,Yaakov Stern,Philip Scheltens,Jeffrey L. Cummings +37 more
TL;DR: It is proposed that downstream topographical biomarkers of the disease, such as volumetric MRI and fluorodeoxyglucose PET, might better serve in the measurement and monitoring of the course of disease.
Journal ArticleDOI
Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease
Stephen Salloway,Reisa A. Sperling,Nick C. Fox,Kaj Blennow,William E. Klunk,Murray A. Raskind,Marwan N. Sabbagh,Lawrence S. Honig,Anton P. Porsteinsson,Steven H. Ferris,Marcel Reichert,Nzeera Ketter,Bijan Nejadnik,Volkmar Guenzler,Maja Miloslavsky,Daniel Wang,Yuan Lu,Julia Lull,Iulia Cristina Tudor,Enchi Liu,Michael Grundman,Eric C. Yuen,Ronald Black,H. Robert Brashear +23 more
TL;DR: Bapineuzumab did not improve clinical outcomes in patients with Alzheimer's disease, despite treatment differences in biomarkers observed in APOE ε4 carriers.
Journal ArticleDOI
CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis
Bob Olsson,Ronald Lautner,Ulf Andreasson,Annika Öhrfelt,Erik Portelius,Maria Bjerke,Maria Bjerke,Mikko Hölttä,Christoffer Rosén,Caroline Olsson,Gabrielle Strobel,Elizabeth Wu,Kelly Dakin,Max Petzold,Max Petzold,Kaj Blennow,Henrik Zetterberg,Henrik Zetterberg +17 more
TL;DR: The core CSF biomarkers of neurodegeneration (T-tau, P-tAU, and Aβ42), CSF NFL, and plasma T-t Tau were strongly associated with Alzheimer's disease and the core biomarkers were strong associated with mild cognitive impairment due to Alzheimer's Disease.
Journal ArticleDOI
Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.
Bruno Dubois,Harald Hampel,Harald Hampel,Howard Feldman,Philip Scheltens,Paul S. Aisen,Sandrine Andrieu,Hovagim Bakardjian,Habib Benali,Lars Bertram,Lars Bertram,Kaj Blennow,Karl Broich,Enrica Cavedo,Sebastian J. Crutch,Jean-François Dartigues,Charles Duyckaerts,Stéphane Epelbaum,Giovanni B. Frisoni,Serge Gauthier,Remy Genthon,Alida A. Gouw,Alida A. Gouw,Marie-Odile Habert,David M. Holtzman,Miia Kivipelto,Miia Kivipelto,Simone Lista,José Luis Molinuevo,Sid E. O'Bryant,Gil D. Rabinovici,Christopher C. Rowe,Stephen Salloway,Lon S. Schneider,Reisa A. Sperling,Reisa A. Sperling,Marc Teichmann,Maria C. Carrillo,Jeffrey L. Cummings,Cliff R. Jack +39 more
TL;DR: An updated review of the literature and evidence on the definitions and lexicon, the limits, the natural history, the markers of progression, and the ethical consequence of detecting the disease at this asymptomatic stage of Alzheimer's disease are provided.
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