E
Eric O. Johnson
Researcher at Research Triangle Park
Publications - 208
Citations - 14180
Eric O. Johnson is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 54, co-authored 190 publications receiving 11942 citations. Previous affiliations of Eric O. Johnson include University of Pennsylvania & Johns Hopkins University.
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Journal ArticleDOI
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
Scott F. Saccone,Anthony L. Hinrichs,Nancy L. Saccone,Gary A. Chase,Karel Konvicka,Pamela A. F. Madden,Naomi Breslau,Eric O. Johnson,Dorothy K. Hatsukami,Ovide F. Pomerleau,Gary E. Swan,Alison Goate,Joni L. Rutter,Sarah Bertelsen,Louis Fox,Douglas A. Fugman,Nicholas G. Martin,Grant W. Montgomery,Jen C. Wang,Dennis G. Ballinger,John P. Rice,Laura J. Bierut +21 more
TL;DR: This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies.
Journal ArticleDOI
The association of insomnia with anxiety disorders and depression: Exploration of the direction of risk
TL;DR: Results suggest distinct natural courses of development between DSM-IV insomnia, anxiety, and depression during adolescence, and insomnia may have independent, and potentially etiologically distinct, directional associations with anxiety disorders versus depression.
Journal ArticleDOI
Novel genes identified in a high-density genome wide association study for nicotine dependence
Laura J. Bierut,Pamela A. F. Madden,Naomi Breslau,Eric O. Johnson,Dorothy K. Hatsukami,Ovide F. Pomerleau,Gary E. Swan,Joni L. Rutter,Sarah Bertelsen,Louis Fox,Douglas A. Fugman,Alison Goate,Anthony L. Hinrichs,Karel Konvicka,Nicholas G. Martin,Grant W. Montgomery,Nancy L. Saccone,Scott F. Saccone,Jen C. Wang,Gary A. Chase,John P. Rice,Dennis G. Ballinger +21 more
TL;DR: This study nominates several novel genes, such as Neurexin 1 (NRXN1), in the development of nicotine dependence while also identifying a known candidate gene, the beta3 nicotinic cholinergic receptor.
Journal ArticleDOI
Variants in nicotinic receptors and risk for nicotine dependence
Laura J. Bierut,Jerry A. Stitzel,Jen C. Wang,Anthony L. Hinrichs,Richard A. Grucza,Xiaoling Xuei,Nancy L. Saccone,Scott F. Saccone,Sarah Bertelsen,Louis Fox,William J. Horton,Naomi Breslau,John P. Budde,C. Robert Cloninger,Danielle M. Dick,Tatiana Foroud,Dorothy K. Hatsukami,Victor Hesselbrock,Eric O. Johnson,John Kramer,Samuel Kuperman,Pamela A. F. Madden,Kevin Mayo,John I. Nurnberger,Ovide F. Pomerleau,Bernice Porjesz,Oliver Reyes,Marc A. Schuckit,Gary E. Swan,Jay A. Tischfield,Howard J. Edenberg,John P. Rice,Alison Goate +32 more
TL;DR: This study confirms that at least two independent variants in this nicotinic receptor gene cluster contribute to the development of habitual smoking in some populations, and it underscores the importance of multiple genetic variants contributing to theDevelopment of common diseases in various populations.
Journal ArticleDOI
A genome-wide association study of alcohol dependence
Laura J. Bierut,Arpana Agrawal,Kathleen K. Bucholz,Kimberly F. Doheny,Cathy C. Laurie,Elizabeth W. Pugh,Sherri L. Fisher,Louis Fox,William Howells,Sarah Bertelsen,Anthony L. Hinrichs,Laura Almasy,Naomi Breslau,Robert Culverhouse,Danielle M. Dick,Howard J. Edenberg,Tatiana Foroud,Richard A. Grucza,Dorothy K. Hatsukami,Victor Hesselbrock,Eric O. Johnson,John Kramer,Robert F. Krueger,Samuel Kuperman,Michael T. Lynskey,Karl Mann,Rosalind J. Neuman,Markus M. Nöthen,John I. Nurnberger,Bernice Porjesz,Monika Ridinger,Nancy L. Saccone,Scott F. Saccone,Marc A. Schuckit,Jay A. Tischfield,Jen C. Wang,Marcella Rietschel,Alison Goate,John P. Rice +38 more
TL;DR: The dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence.