J
Jen C. Wang
Researcher at Washington University in St. Louis
Publications - 52
Citations - 7179
Jen C. Wang is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Alcohol dependence & Single-nucleotide polymorphism. The author has an hindex of 39, co-authored 51 publications receiving 6866 citations. Previous affiliations of Jen C. Wang include Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
Scott F. Saccone,Anthony L. Hinrichs,Nancy L. Saccone,Gary A. Chase,Karel Konvicka,Pamela A. F. Madden,Naomi Breslau,Eric O. Johnson,Dorothy K. Hatsukami,Ovide F. Pomerleau,Gary E. Swan,Alison Goate,Joni L. Rutter,Sarah Bertelsen,Louis Fox,Douglas A. Fugman,Nicholas G. Martin,Grant W. Montgomery,Jen C. Wang,Dennis G. Ballinger,John P. Rice,Laura J. Bierut +21 more
TL;DR: This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies.
Journal ArticleDOI
Novel genes identified in a high-density genome wide association study for nicotine dependence
Laura J. Bierut,Pamela A. F. Madden,Naomi Breslau,Eric O. Johnson,Dorothy K. Hatsukami,Ovide F. Pomerleau,Gary E. Swan,Joni L. Rutter,Sarah Bertelsen,Louis Fox,Douglas A. Fugman,Alison Goate,Anthony L. Hinrichs,Karel Konvicka,Nicholas G. Martin,Grant W. Montgomery,Nancy L. Saccone,Scott F. Saccone,Jen C. Wang,Gary A. Chase,John P. Rice,Dennis G. Ballinger +21 more
TL;DR: This study nominates several novel genes, such as Neurexin 1 (NRXN1), in the development of nicotine dependence while also identifying a known candidate gene, the beta3 nicotinic cholinergic receptor.
Journal ArticleDOI
Variants in nicotinic receptors and risk for nicotine dependence
Laura J. Bierut,Jerry A. Stitzel,Jen C. Wang,Anthony L. Hinrichs,Richard A. Grucza,Xiaoling Xuei,Nancy L. Saccone,Scott F. Saccone,Sarah Bertelsen,Louis Fox,William J. Horton,Naomi Breslau,John P. Budde,C. Robert Cloninger,Danielle M. Dick,Tatiana Foroud,Dorothy K. Hatsukami,Victor Hesselbrock,Eric O. Johnson,John Kramer,Samuel Kuperman,Pamela A. F. Madden,Kevin Mayo,John I. Nurnberger,Ovide F. Pomerleau,Bernice Porjesz,Oliver Reyes,Marc A. Schuckit,Gary E. Swan,Jay A. Tischfield,Howard J. Edenberg,John P. Rice,Alison Goate +32 more
TL;DR: This study confirms that at least two independent variants in this nicotinic receptor gene cluster contribute to the development of habitual smoking in some populations, and it underscores the importance of multiple genetic variants contributing to theDevelopment of common diseases in various populations.
Journal ArticleDOI
A genome-wide association study of alcohol dependence
Laura J. Bierut,Arpana Agrawal,Kathleen K. Bucholz,Kimberly F. Doheny,Cathy C. Laurie,Elizabeth W. Pugh,Sherri L. Fisher,Louis Fox,William Howells,Sarah Bertelsen,Anthony L. Hinrichs,Laura Almasy,Naomi Breslau,Robert Culverhouse,Danielle M. Dick,Howard J. Edenberg,Tatiana Foroud,Richard A. Grucza,Dorothy K. Hatsukami,Victor Hesselbrock,Eric O. Johnson,John Kramer,Robert F. Krueger,Samuel Kuperman,Michael T. Lynskey,Karl Mann,Rosalind J. Neuman,Markus M. Nöthen,John I. Nurnberger,Bernice Porjesz,Monika Ridinger,Nancy L. Saccone,Scott F. Saccone,Marc A. Schuckit,Jay A. Tischfield,Jen C. Wang,Marcella Rietschel,Alison Goate,John P. Rice +38 more
TL;DR: The dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence.
Journal ArticleDOI
Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD
Nancy L. Saccone,Nancy L. Saccone,Robert Culverhouse,Tae-Hwi Schwantes-An,Dale S. Cannon,Xiangning Chen,Sven Cichon,Ina Giegling,Shizhong Han,Younghun Han,Kaisu Keskitalo-Vuokko,Xiangyang Kong,Maria Teresa Landi,Jennie Z. Ma,Susan E. Short,Susan E. Short,Sarah H. Stephens,Victoria L. Stevens,Lingwei Sun,Yufei Wang,Angela S. Wenzlaff,Steven H. Aggen,Naomi Breslau,Peter Broderick,Nilanjan Chatterjee,Jingchun Chen,Andrew C. Heath,Markku Heliövaara,Nicole R. Hoft,David J. Hunter,Majken K. Jensen,Nicholas G. Martin,Grant W. Montgomery,Tianhua Niu,Thomas J. Payne,Leena Peltonen,Michele L. Pergadia,John P. Rice,Richard Sherva,Margaret R. Spitz,Juzhong Sun,Jen C. Wang,Robert B. Weiss,William Wheeler,Stephanie H. Witt,Bao-Zhu Yang,Neil E. Caporaso,Marissa A. Ehringer,Tim Eisen,Susan M. Gapstur,Joel Gelernter,Richard S. Houlston,Jaakko Kaprio,Jaakko Kaprio,Kenneth S. Kendler,Peter Kraft,Mark Leppert,Ming D. Li,Pamela A. F. Madden,Markus M. Nöthen,Sreekumar G. Pillai,Marcella Rietschel,Dan Rujescu,Ann G. Schwartz,Christopher I. Amos,Laura J. Bierut +65 more
TL;DR: This study provides strong evidence that multiple statistically distinct loci in this region affect smoking behavior, and is the first report of association between rs588765 (and correlates) and smoking that achieves genome-wide significance.