E
Esme C. Hatchell
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 4
Citations - 1008
Esme C. Hatchell is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Necroptosis & Missense mutation. The author has an hindex of 4, co-authored 4 publications receiving 782 citations. Previous affiliations of Esme C. Hatchell include University of Melbourne.
Papers
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Journal ArticleDOI
The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
James M. Murphy,Peter E. Czabotar,Peter E. Czabotar,Joanne M Hildebrand,Joanne M Hildebrand,Isabelle S Lucet,Jian-Guo Zhang,Jian-Guo Zhang,Silvia Alvarez-Diaz,Silvia Alvarez-Diaz,Rowena S. Lewis,Rowena S. Lewis,Najoua Lalaoui,Najoua Lalaoui,Donald Metcalf,Donald Metcalf,Andrew I. Webb,Andrew I. Webb,Samuel N. Young,Samuel N. Young,Leila N. Varghese,Leila N. Varghese,Gillian M. Tannahill,Gillian M. Tannahill,Esme C. Hatchell,Esme C. Hatchell,Ian J. Majewski,Ian J. Majewski,Toru Okamoto,Toru Okamoto,Renwick C. J. Dobson,Renwick C. J. Dobson,Douglas J. Hilton,Douglas J. Hilton,Jeffrey J. Babon,Jeffrey J. Babon,Nicos A. Nicola,Nicos A. Nicola,Andreas Strasser,Andreas Strasser,John Silke,John Silke,Warren S. Alexander,Warren S. Alexander +43 more
TL;DR: Structural-guided mutation of the MLKL pseudoactive site resulted in constitutive, RIPK3-independent necroptosis, demonstrating that modification ofMLKL is essential for propagation of the ne croptosis pathway downstream of RIPK 3.
Journal ArticleDOI
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
Joanne M Hildebrand,Joanne M Hildebrand,Maria Kauppi,Maria Kauppi,Ian J. Majewski,Ian J. Majewski,Zikou Liu,Zikou Liu,Allison Cox,Sanae Miyake,Emma J. Petrie,Emma J. Petrie,Michael A. Silk,Michael A. Silk,Zhixiu Li,Maria C. Tanzer,Maria C. Tanzer,Maria C. Tanzer,Gabriela Brumatti,Gabriela Brumatti,Samuel N. Young,Samuel N. Young,Cathrine Hall,Cathrine Hall,Sarah E Garnish,Sarah E Garnish,Jason Corbin,Jason Corbin,Michael D. Stutz,Michael D. Stutz,Michael D. Stutz,Ladina Di Rago,Ladina Di Rago,Pradnya Gangatirkar,Pradnya Gangatirkar,Emma C. Josefsson,Emma C. Josefsson,Kristin A Rigbye,Kristin A Rigbye,Holly Anderton,Holly Anderton,James A Rickard,James A Rickard,James A Rickard,Anne Tripaydonis,Anne Tripaydonis,Anne Tripaydonis,Julie Sheridan,Julie Sheridan,Thomas S. Scerri,Thomas S. Scerri,Victoria E. Jackson,Victoria E. Jackson,Peter E. Czabotar,Peter E. Czabotar,Jian-Guo Zhang,Jian-Guo Zhang,Leila N. Varghese,Leila N. Varghese,Leila N. Varghese,Cody C. Allison,Cody C. Allison,Marc Pellegrini,Marc Pellegrini,Gillian M. Tannahill,Gillian M. Tannahill,Esme C. Hatchell,Esme C. Hatchell,Tracy A. Willson,Tracy A. Willson,Dina Stockwell,Dina Stockwell,Carolyn A. de Graaf,Carolyn A. de Graaf,Janelle E. Collinge,Janelle E. Collinge,Adrienne A. Hilton,Natasha Silke,Natasha Silke,Sukhdeep K Spall,Sukhdeep K Spall,Diep Chau,Diep Chau,Diep Chau,Vicki Athanasopoulos,Vicki Athanasopoulos,Donald Metcalf,Donald Metcalf,Ronald M. Laxer,Alexander G. Bassuk,Benjamin W. Darbro,Maria A. Fiatarone Singh,Nicole Vlahovich,David Hughes,Maria Kozlovskaia,Maria Kozlovskaia,David B. Ascher,David B. Ascher,Klaus Warnatz,Nils Venhoff,Jens Thiel,Christine Biben,Christine Biben,Stefan Blum,John Reveille,Michael S. Hildebrand,Michael S. Hildebrand,Carola G. Vinuesa,Carola G. Vinuesa,Pamela A. McCombe,Matthew A. Brown,Matthew A. Brown,Benjamin T. Kile,Benjamin T. Kile,Benjamin T. Kile,Catriona McLean,Melanie Bahlo,Melanie Bahlo,Seth L. Masters,Seth L. Masters,Hiroyasu Nakano,Polly J. Ferguson,James M. Murphy,James M. Murphy,Warren S. Alexander,Warren S. Alexander,John Silke,John Silke +127 more
TL;DR: A mutation in the brace region that confers constitutive activation, leading to lethal inflammation in homozygous mutant mice and providing insight into human mutations in this region is identified.
Posted ContentDOI
Missense mutations in the MLKL ‘brace’ region lead to lethal neonatal inflammation in mice and are present in high frequency in humans
Joanne M Hildebrand,Joanne M Hildebrand,Maria Kauppi,Maria Kauppi,Ian J. Majewski,Ian J. Majewski,Zikou Liu,Zikou Liu,Allison Cox,Sanae Miyake,Emma J. Petrie,Emma J. Petrie,Michael A. Silk,Michael A. Silk,Zhixiu Li,Maria C. Tanzer,Maria C. Tanzer,Samuel N. Young,Samuel N. Young,Cathrine Hall,Cathrine Hall,Sarah E Garnish,Sarah E Garnish,Jason Corbin,Jason Corbin,Michael D. Stutz,Michael D. Stutz,Pradnya Gangatirkar,Pradnya Gangatirkar,Emma C. Josefsson,Emma C. Josefsson,Kristin A Rigbye,Kristin A Rigbye,Holly Anderton,Holly Anderton,James A Rickard,James A Rickard,Anne Tripaydonis,Anne Tripaydonis,Julie Sheridan,Julie Sheridan,Thomas S. Scerri,Thomas S. Scerri,Peter A. Czabotar,Peter A. Czabotar,Jian-Guo Zhang,Jian-Guo Zhang,Cody C. Allison,Cody C. Allison,Marc Pellegrini,Marc Pellegrini,Gillian M. Tannahill,Gillian M. Tannahill,Esme C. Hatchell,Esme C. Hatchell,Tracy A. Willson,Tracy A. Willson,Dina Stockwell,Dina Stockwell,Carolyn A. de Graaf,Carolyn A. de Graaf,Janelle E. Collinge,Janelle E. Collinge,Adrienne A. Hilton,Natasha Silke,Natasha Silke,Sukhdeep K Spall,Sukhdeep K Spall,Diep Chau,Diep Chau,Vicki Athanasopoulos,Donald Metcalf,Donald Metcalf,Ronald M. Laxer,Alexander G. Bassuk,Benjamin W. Darbro,Maria A. Fiatarone Singh,Nicole Vlahovich,David Hughes,Maria Kozlovskaia,David B. Ascher,David B. Ascher,Klaus Warnatz,Nils Venhoff,Jens Thiel,Stefan Blum,John Reveille,Michael S. Hildebrand,Michael S. Hildebrand,Carola G. Vinuesa,Pamela A. McCombe,Matthew A. Brown,Ben T. Kile,Ben T. Kile,Catriona McLean,Melanie Bahlo,Melanie Bahlo,Seth L. Masters,Seth L. Masters,Hiroyasu Nakano,Polly J. Ferguson,James M. Murphy,James M. Murphy,Warren S. Alexander,Warren S. Alexander,John Silke,John Silke +106 more
TL;DR: A mouse strain with a single missense mutation in the gene encoding MLKL, the essential effector of necroptotic cell death, is isolated and the resulting substitution lies within the two-helix ‘brace’ and confers constitutive, RIPK3 independent, killing activity toMLKL.
Patent
Methods and agents for modulating kinase signalling pathways through modulation of mixed-lineage kinase domain-like protein (mlkl)
Warren S. Alexander,Esme C. Hatchell,Douglas J. Hilton,Ian J. Majewski,James M. Murphy,Gillian M. Tannahill +5 more
TL;DR: In this article, methods and agents for modulating kinase signalling and cytokine signalling activity in a subject or cell by agonising or antagonising the activity of mixed-lineage kinase domain-like protein (MLKL).