Fabrizio Tagliavini

TL;DR: In this paper, a screening method carried out on biological material isolated from human and/or animal organisms for determining the risk of human and animal pathologies expressing an anomalous deposition of β-amyloid and or amyloid-like substance in human or animal organs and tissues, based on the investigation of the punctiform mutation Ala>Val in position 2 of the β-protein (corresponding to the Ala673Val mutation precursor of theβ-protein containing 770 amino acids) in homozygosis or in heterozygosis.

TL;DR: In this paper, a method based on deep learning was proposed for segmentation of amyloid PET studies using U-Net for a validation cohort of N=20 patients, even when using only N=14 patients in the training dataset.

TL;DR: In this article , the potential therapeutic capacity of an all-D-isomer synthetic peptide limited to the first six amino acids of the N-terminal sequence of the A2V-mutated Aβ, Aβ1-6A2V(D), was explored.

TL;DR: This paper tested whether changes in functional networks predict cognitive decline and conversion from the presymptomatic prodrome to symptomatic disease in familial frontotemporal dementia (FTD) and found that functional networks predicted cognitive decline.