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Robert Laforce
Researcher at Laval University
Publications - 206
Citations - 5266
Robert Laforce is an academic researcher from Laval University. The author has contributed to research in topics: Frontotemporal dementia & Dementia. The author has an hindex of 29, co-authored 168 publications receiving 3526 citations. Previous affiliations of Robert Laforce include Helen Wills Neuroscience Institute & École Normale Supérieure.
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Journal ArticleDOI
Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis
Jonathan D. Rohrer,Jennifer M. Nicholas,Jennifer M. Nicholas,David M. Cash,John C. van Swieten,Elise G.P. Dopper,Lize C. Jiskoot,Rick van Minkelen,Serge A.R.B. Rombouts,M. Jorge Cardoso,Shona Clegg,Miklos Espak,Simon Mead,David L. Thomas,Enrico De Vita,Mario Masellis,Sandra E. Black,Morris Freedman,Ron Keren,Bradley J. MacIntosh,Ekaterina Rogaeva,David F. Tang-Wai,Maria Carmela Tartaglia,Robert Laforce,Fabrizio Tagliavini,Pietro Tiraboschi,Veronica Redaelli,Sara Prioni,Marina Grisoli,Barbara Borroni,Alessandro Padovani,Daniela Galimberti,Elio Scarpini,Andrea Arighi,Giorgio G. Fumagalli,James B. Rowe,Ian Coyle-Gilchrist,Caroline Graff,Caroline Graff,Marie Fallström,Vesna Jelic,Vesna Jelic,Anne Kinhult Ståhlbom,Anne Kinhult Ståhlbom,Christin Andersson,Christin Andersson,Håkan Thonberg,Håkan Thonberg,Lena Lilius,Giovanni B. Frisoni,Giuliano Binetti,Michela Pievani,Martina Bocchetta,Luisa Benussi,Roberta Ghidoni,Elizabeth Finger,Sandro Sorbi,Benedetta Nacmias,Gemma Lombardi,Cristina Polito,Jason D. Warren,Sebastien Ourselin,Nick C. Fox,Martin N. Rossor +63 more
TL;DR: Structural imaging and cognitive changes can be identified 5-10 years before expected onset of symptoms in asymptomatic adults at risk of genetic frontotemporal dementia, which could help to define biomarkers that can stage presymPTomatic disease and track disease progression.
Journal ArticleDOI
Role of the striatum, cerebellum, and frontal lobes in the learning of a visuomotor sequence.
Julien Doyon,Gaudreau D,Robert Laforce,Castonguay M,Bédard Pj,Fernand Bédard,Jean-Pierre Bouchard +6 more
TL;DR: It is suggested that, unlike declarative memory, the incremental acquisition of a new visuomotor skill depends upon the integrity of both the striatum and the cerebellum, but not of the frontal lobes.
Journal ArticleDOI
Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease
Manja Lehmann,Manja Lehmann,Manja Lehmann,Pia Ghosh,Pia Ghosh,Cindee Madison,Robert Laforce,Robert Laforce,Chiara Corbetta-Rastelli,Michael W. Weiner,Michael D. Greicius,William W. Seeley,Maria Luisa Gorno-Tempini,Howard J. Rosen,Bruce L. Miller,William J. Jagust,William J. Jagust,William J. Jagust,Gil D. Rabinovici,Gil D. Rabinovici,Gil D. Rabinovici +20 more
TL;DR: Alzheimer's disease syndromes are associated with degeneration of specific functional networks, and that fibrillar amyloid-β deposition explains at most a small amount of the clinico-anatomic heterogeneity in Alzheimer's disease.
Journal ArticleDOI
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference
Alexandra L. Young,Razvan V. Marinescu,Neil P. Oxtoby,Martina Bocchetta,Keir Yong,Nicholas C. Firth,David M. Cash,David L. Thomas,Katrina M. Dick,Jorge Cardoso,Jorge Cardoso,John C. van Swieten,Barbara Borroni,Daniela Galimberti,Daniela Galimberti,Mario Masellis,Maria Carmela Tartaglia,James B. Rowe,Caroline Graff,Fabrizio Tagliavini,Giovanni B. Frisoni,Robert Laforce,Elizabeth Finger,Alexandre de Mendonça,Sandro Sorbi,Jason D. Warren,Sebastian J. Crutch,Nick C. Fox,Sebastien Ourselin,Jonathan M. Schott,Jonathan D. Rohrer,Daniel C. Alexander +31 more
TL;DR: A machine-learning technique—Subtype and Stage Inference (SuStaIn)—able to uncover data-driven disease phenotypes with distinct temporal progression patterns, from widely available cross-sectional patient studies is introduced, using two neurodegenerative disease cohorts.
Journal ArticleDOI
Neurofilament light chain: a biomarker for genetic frontotemporal dementia.
Lieke H.H. Meeter,Elise G.P. Dopper,Lize C. Jiskoot,Raquel Sánchez-Valle,Caroline Graff,Caroline Graff,Luisa Benussi,Roberta Ghidoni,Yolande A.L. Pijnenburg,Barbara Borroni,Daniela Galimberti,Robert Laforce,Mario Masellis,Mario Masellis,Rik Vandenberghe,Isabelle Le Ber,Markus Otto,Rick van Minkelen,Janne M. Papma,Serge A.R.B. Rombouts,Serge A.R.B. Rombouts,Mircea Balasa,Linn Öijerstedt,Linn Öijerstedt,Vesna Jelic,Vesna Jelic,Katrina M. Dick,David M. Cash,David M. Cash,S. Harding,M. Jorge Cardoso,Sebastien Ourselin,Martin N. Rossor,Alessandro Padovani,Elio Scarpini,Chiara Fenoglio,Maria Carmela Tartaglia,Foudil Lamari,Christian Barro,Jens Kuhle,Jonathan D. Rohrer,Charlotte E. Teunissen,John C. van Swieten,John C. van Swieten +43 more
TL;DR: To evaluate cerebrospinal fluid and serum neurofilament light chain levels in genetic frontotemporal dementia (FTD) as a potential biomarker in the presymptomatic stage and during the conversion into the symptomatic stage.