F
Farooq Rahman
Researcher at University College London Hospitals NHS Foundation Trust
Publications - 67
Citations - 2088
Farooq Rahman is an academic researcher from University College London Hospitals NHS Foundation Trust. The author has contributed to research in topics: Parenteral nutrition & Crohn's disease. The author has an hindex of 20, co-authored 60 publications receiving 1772 citations. Previous affiliations of Farooq Rahman include University College Hospital & University College London.
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Journal ArticleDOI
Defective acute inflammation in Crohn's disease : a clinical investigation
Daniel Marks,Marcus Harbord,Raymond J. MacAllister,Farooq Rahman,Jodi N. Young,Bissan Al-Lazikani,William R. Lees,Marco Novelli,Stuart Bloom,Anthony W. Segal +9 more
TL;DR: In Crohn's disease, a constitutionally weak immune response predisposes to accumulation of intestinal contents that breach the mucosal barrier of the bowel wall, resulting in granuloma formation and chronic inflammation, and current treatment of secondary chronic inflammation might exaggerate the underlying lesion and promote chronic disease.
Journal ArticleDOI
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease
Andrew M. Smith,Farooq Rahman,Bu’Hussain Hayee,Simon J Graham,Daniel Marks,Gavin W. Sewell,Christine D. Palmer,Jonathan I. Wilde,Brian M. J. Foxwell,Israel S. Gloger,Trevor J. Sweeting,Mark Marsh,Ann P. Walker,Stuart Bloom,Anthony W. Segal +14 more
TL;DR: It is suggested that in CD macrophages, an abnormal proportion of cytokines are routed to lysosomes and degraded rather than being released through the normal secretory pathway, which indicates accelerated intracellular breakdown.
Journal ArticleDOI
Inflammatory bowel disease in CGD reproduces the clinicopathological features of Crohn's disease.
TL;DR: There are striking clinical and pathological resemblances between the bowel diseases observed in CGD and Crohn's disease, supporting the possibility of mechanistic similarities in their pathogenesis.
Journal ArticleDOI
Diagnostic accuracy of magnetic resonance enterography and small bowel ultrasound for the extent and activity of newly diagnosed and relapsed Crohn's disease (METRIC): a multicentre trial.
Stuart A. Taylor,Susan Mallett,Gauraang Bhatnagar,Rachel Baldwin-Cleland,Stuart Bloom,Arun Gupta,PJ Hamlin,Ailsa Hart,Antony Higginson,Ilan Jacobs,Sara McCartney,Anne Miles,Charles Murray,Andrew Plumb,Richard Pollok,Shonit Punwani,Laura L. Quinn,Manuel Rodriguez-Justo,Zainib Shabir,A Slater,Damian Tolan,Simon Travis,Alastair Windsor,Peter Wylie,Ian Zealley,Steve Halligan,Jade Dyer,Pranitha Veeramalla,Sue Tebbs,Steve Hibbert,Richard Ellis,Fergus Thursby-Pelham,Richard Beable,Nicola Gibbons,Claire Ward,Anthony O'Connor,Hannah Lambie,Rachel Hyland,Nigel Scott,Roger Lapham,Doris Quartey,Deborah Scrimshaw,Helen Bungay,Maggie Betts,Simona Fourie,Niall Power,Rajapandian Ilangovan,Uday Patel,Evgenia Mainta,Phillip Lung,Ian Johnston,Mani Naghibi,Morgan Moorghen,Adriana Martinez,Francois Porte,C Alexakis,James Pilcher,Anisur Rahman,Jonny Vlahos,R Greenhalgh,Anita Wale,Teresita Beeston,Wivijin Piga,Joey Clemente,Farooq Rahman,Simona de Caro,Shameer Mehta,Roser Vega,Roman Jastrub,Harbir S. Sidhu,Hameed Rafiee,Mairead Tennent,Caron Innes,Craig Mowat,Gillian Duncan,Steve Morris +75 more
TL;DR: Both MRE and ultrasound have high sensitivity for detecting small bowel disease presence and both are valid first-line investigations, and viable alternatives to ileocolonoscopy.
Journal ArticleDOI
Crohn’s Disease: an Immune Deficiency State
TL;DR: A substantial body of data has emerged in recent years to suggest that the primary defect in Crohn’s disease is actually one of relative immunodeficiency, and the evidence for such a phenomenon is considered in contrast to alternative prevailing hypotheses and some of the potential paradoxes that it generates.