F
Fatima Verissimo
Researcher at European Bioinformatics Institute
Publications - 8
Citations - 737
Fatima Verissimo is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Endoplasmic reticulum & COPII. The author has an hindex of 6, co-authored 8 publications receiving 668 citations.
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Journal ArticleDOI
Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II.
Klaus Schwarz,Klaus Schwarz,Achille Iolascon,Fatima Verissimo,Nikolaus S. Trede,Nikolaus S. Trede,Wyatt Horsley,Wyatt Horsley,Wen Chen,Barry H. Paw,Karl-Peter Hopfner,Karlheinz Holzmann,Roberta Russo,Maria Rosaria Esposito,Daniela Spano,Luigia De Falco,Katja Heinrich,Brigitte Joggerst,Markus Rojewski,Markus Rojewski,Silverio Perrotta,Jonas Denecke,Ulrich Pannicke,Jean Delaunay,Rainer Pepperkok,Hermann Heimpel +25 more
TL;DR: The results provide in vivo evidence forSEC23B selectivity in erythroid differentiation and show that SEC23A and SEC23B, although highly related paralogous secretory COPII components, are nonredundant in ERYthrocyte maturation.
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Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway
Jeremy C. Simpson,Brigitte Joggerst,Vibor Laketa,Fatima Verissimo,Cihan Cetin,Holger Erfle,Holger Erfle,Mariana G. Bexiga,Vasanth R. Singan,Jean-Karim Hériché,Beate Neumann,Alvaro Mateos,Jonathon Blake,Stephanie Bechtel,Vladimir Benes,Stefan Wiemann,Jan Ellenberg,Rainer Pepperkok +17 more
TL;DR: Network analyses revealed a so far unappreciated link between early secretory pathway function, small GTP-binding protein regulation, actin cytoskeleton organization and EGF-receptor-mediated signalling.
Journal ArticleDOI
Secretory Cargo Regulates the Turnover of COPII Subunits at Single ER Exit Sites
Rebecca Forster,Matthias Weiss,Timo Zimmermann,Emmanuel G. Reynaud,Fatima Verissimo,David J. Stephens,Rainer Pepperkok +6 more
TL;DR: A mathematical model of COPII membrane turnover that reproduces the experimental in vivo FRAP kinetics and is consistent with existing in vitro data predicts that Sec23/24p remains membrane associated even after GTP hydrolysis by Sar1p for a duration that is strongly increased by the presence of cargo.
Journal ArticleDOI
Micropilot: automation of fluorescence microscopy–based imaging for systems biology
Christian Conrad,Annelie Wünsche,Tze Heng Tan,Jutta Bulkescher,Frank Sieckmann,Fatima Verissimo,Arthur D. Edelstein,Thomas Walter,Urban Liebel,Rainer Pepperkok,Jan Ellenberg +10 more
TL;DR: The 'Micropilot' software automatically detects cells of interest and launches complex imaging experiments including three-dimensional multicolor time-lapse or fluorescence recovery after photobleaching in live cells, allowing us to statistically analyze biological processes in detail.
Journal ArticleDOI
Imaging ER-to-Golgi transport: towards a systems view
TL;DR: Examples that revealed the dynamic organisation of ER- to-Golgi transport in living cells are outlined and the use of advanced imaging methods in studying ER-to-G Golgi transport is discussed, to delineate the efforts in understanding ER-To-Gollgi transport at the systems level.