Fengyan Yu

TL;DR: Let-7 regulates multiple BT-IC stem cell-like properties by silencing more than one target, and miRNA expression in self-renewing and differentiated cells from breast cancer lines and in breast T-IC and non-BT-IC from 1 degrees breast cancers is compared.

TL;DR: In this article, the authors show that breast TAMs abundantly produce CCL18, and its expression in blood or cancer stroma is associated with metastasis and reduced patient survival.

TL;DR: Expression of miR-200, which promotes a mesenchymal to epithelial cell transition (MET) by inhibiting Zeb2 expression, unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines, suggesting that for some tumors, tumor colonization at metastatic sites might be enhanced by MET.

TL;DR: The data suggest mir-30 as one of the important miRNAs in regulating the stem-like features of T-ICs, which have a pivotal role in tumorigenesis, tumor progression, metastasis and post-treatment relapse.

TL;DR: Reduction in miR-128 leading to Bmi-1 and ABCC5 overexpression is a stem cell–like feature of BT-ICs, which contributes to chemotherapeutic resistance in breast cancers.