F
Filip Mundt
Researcher at Broad Institute
Publications - 30
Citations - 2551
Filip Mundt is an academic researcher from Broad Institute. The author has contributed to research in topics: Proteomics & Transcriptome. The author has an hindex of 16, co-authored 25 publications receiving 1796 citations. Previous affiliations of Filip Mundt include Karolinska University Hospital & Massachusetts Institute of Technology.
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Journal ArticleDOI
Proteogenomics connects somatic mutations to signalling in breast cancer
Philipp Mertins,D. R. Mani,Kelly V. Ruggles,Michael A. Gillette,Michael A. Gillette,Karl R. Clauser,Pei Wang,Xianlong Wang,Jana W. Qiao,Song Cao,Francesca Petralia,Emily Kawaler,Filip Mundt,Filip Mundt,Karsten Krug,Zhidong Tu,Jonathan T. Lei,Michael L. Gatza,Matthew D. Wilkerson,Charles M. Perou,Venkata Yellapantula,Kuan-lin Huang,Chenwei Lin,Michael D. McLellan,Ping Yan,Sherri R. Davies,R. Reid Townsend,Steven J. Skates,Jing Wang,Bing Zhang,Christopher R. Kinsinger,Mehdi Mesri,Henry Rodriguez,Li Ding,Amanda G. Paulovich,David Fenyö,Matthew J. Ellis,Steven A. Carr +37 more
TL;DR: It is demonstrated that proteogenomic analysis of breast cancer elucidates functional consequences of somatic mutations, narrows candidate nominations for driver genes within large deletions and amplified regions, and identifies therapeutic targets.
Journal ArticleDOI
Reproducible workflow for multiplexed deep-scale proteome and phosphoproteome analysis of tumor tissues by liquid chromatography-mass spectrometry
Philipp Mertins,Philipp Mertins,Lauren C. Tang,Karsten Krug,David J. Clark,Marina A. Gritsenko,Lijun Chen,Karl R. Clauser,Therese R. W. Clauss,Punit Shah,Michael A. Gillette,Vladislav A. Petyuk,Stefani N. Thomas,D. R. Mani,Filip Mundt,Ronald J. Moore,Yingwei Hu,Rui Zhao,Michael Schnaubelt,Hasmik Keshishian,Matthew E. Monroe,Zhen Zhang,Namrata D. Udeshi,Deepak Mani,Sherri R. Davies,Raymond R. Townsend,Daniel W. Chan,Richard D. Smith,Hui Zhang,Tao Liu,Steven A. Carr +30 more
TL;DR: An optimized workflow for global proteome and phosphoproteome analysis of tissues or cell lines that uses isobaric tags (TMT (tandem mass tags)-10) for multiplexed analysis and relative quantification, and provides 3× higher throughput than iTRAQ-4-based methods with high intra- and inter-laboratory reproducibility is presented.
Journal ArticleDOI
A Curated Resource for Phosphosite-specific Signature Analysis
Karsten Krug,Philipp Mertins,Philipp Mertins,Bin Zhang,Peter Hornbeck,Rajesh Raju,Rushdy Ahmad,Matthew J. Szucs,Matthew J. Szucs,Filip Mundt,Dominique Forestier,Judit Jané-Valbuena,Hasmik Keshishian,Michael A. Gillette,Michael A. Gillette,Pablo Tamayo,Pablo Tamayo,Jill P. Mesirov,Jill P. Mesirov,Jacob D. Jaffe,Steven A. Carr,D. R. Mani +21 more
TL;DR: The first version of PTMsigDB is presented, a database of modification site-specific signatures of perturbations, kinase activities and signaling pathways curated from more than 2,500 publications, and outperformed gene-centric analysis in detection of EGF induced phospho signaling events.
Journal ArticleDOI
Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups
Tenley C. Archer,Tobias Ehrenberger,Filip Mundt,Filip Mundt,Maxwell P. Gold,Karsten Krug,Clarence K. Mah,Elizabeth L. Mahoney,Elizabeth L. Mahoney,Colin J. Daniel,Alexander LeNail,Divya Ramamoorthy,Philipp Mertins,D. R. Mani,Hailei Zhang,Michael A. Gillette,Michael A. Gillette,Karl R. Clauser,Michael S. Noble,Lauren C. Tang,Jessica Pierre-Francois,Jessica Pierre-Francois,Jacob Silterra,James Jensen,Pablo Tamayo,Andrey Korshunov,Andrey Korshunov,Stefan M. Pfister,Stefan M. Pfister,Marcel Kool,Paul A. Northcott,Paul A. Northcott,Rosalie C. Sears,Jonathan O. Lipton,Jonathan O. Lipton,Steven A. Carr,Jill P. Mesirov,Scott L. Pomeroy,Scott L. Pomeroy,Scott L. Pomeroy,Ernest Fraenkel,Ernest Fraenkel +41 more
TL;DR: This study quantitatively profiled global proteomes and phospho-proteomes of 45 medulloblastoma samples and found kinases associated with subtypes and showed that inhibiting PRKDC sensitizes MYC-driven cells to radiation.
Journal ArticleDOI
Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects.
Richard Lindqvist,Filip Mundt,Jonathan D. Gilthorpe,Silke Wölfel,Nelson O. Gekara,Andrea Kröger,Anna K. Överby +6 more
TL;DR: Astrocytes control viral replication of different TBEV strains, JEV, WNV, and ZIKV and suggest that an intrinsic constitutive antiviral response and the fast induction of type I IFN production by astrocyte play an important role in self-protection of astroCytes and suppression of flavivirus replication in the CNS.