Florian Fuchs

TL;DR: EBImage provides general purpose functionality for reading, writing, processing and analysis of images and in the context of microscopy-based cellular assays, EBImage offers tools to segment cells and extract quantitative cellular descriptors.

TL;DR: A systematic screen of a deletion mutant library covering the nonessential genes of Saccharomyces cerevisiae revealed unprecedented mitochondrial phenotypes that have never been observed by conventional screens, providing a comprehensive picture of the cellular processes and molecular components required for mitochondrial function and structure in a simple eukaryotic cell.

TL;DR: Examination of several candidates including the largely uncharacterized gene DONSON, which shared phenotype similarity with known factors of DNA damage response (DDR), supports that DONSON is a novel centrosomal protein required for DDR signalling and genomic integrity.

TL;DR: It is shown that spindle tension is required to cluster multiple centrosomes into a bipolar spindle array in tumor cells with supernumerary centrosome, and that interfering with any of the proteins found in the screen could, in principle, eliminate this tension and prevent bundling, leading to tumor cell death.

TL;DR: It is found that the level of qualification of MPS-based assays for a given context of use and communication gaps between stakeholders are the major challenges slowing industrial adoption by end users, which in turn is causing a regulatory acceptance dilemma.