R
Rhiannon David
Researcher at AstraZeneca
Publications - 34
Citations - 820
Rhiannon David is an academic researcher from AstraZeneca. The author has contributed to research in topics: Carcinogen & Genotoxicity. The author has an hindex of 11, co-authored 29 publications receiving 510 citations. Previous affiliations of Rhiannon David include Imperial College London & University of Birmingham.
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Journal ArticleDOI
On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology.
David B. Chou,David B. Chou,Viktoras Frismantas,Yuka Milton,Rhiannon David,Petar Pop-Damkov,Douglas Ferguson,Alexander MacDonald,Özge Vargel Bölükbaşı,Cailin E. Joyce,Liliana Moreira Teixeira,Arianna Rech,Arianna Rech,Amanda Jiang,Elizabeth Calamari,Sasan Jalili-Firoozinezhad,Sasan Jalili-Firoozinezhad,Brooke A. Furlong,Lucy R. O’Sullivan,Carlos F. Ng,Youngjae Choe,Susan Marquez,Kasiani C. Myers,Kasiani C. Myers,Olga K. Weinberg,Robert P. Hasserjian,Richard M. Novak,Oren Levy,Rachelle Prantil-Baun,Carl D. Novina,Carl D. Novina,Akiko Shimamura,Lorna Ewart,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +35 more
TL;DR: A vascularized human bone-marrow-on-a-chip improves the maintenance of patient-derived CD34 + cells, and recapitulates clinically relevant aspects of bone marrow injury as well as key haematopoietic defects of patients with a rare genetic disorder.
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Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development
Uwe Marx,Akabane T,Tommy B. Andersson,Elizabeth Baker,Mario Beilmann,Beken S,Brendler-Schwaab S,Murat Cirit,Rhiannon David,Dehne Em,Isabell Durieux,Lorna Ewart,Suzanne Fitzpatrick,Olivier Frey,Florian Fuchs,Linda G. Griffith,Geraldine A. Hamilton,Thomas Hartung,Julia Hoeng,Helena T. Hogberg,David J. Hughes,Donald E. Ingber,Anita R. Iskandar,Toshiyuki Kanamori,Kojima H,Kuehnl J,Marcel Leist,Li B,Peter Loskill,Donna L. Mendrick,Neumann T,Giorgia Pallocca,Ivan Rusyn,Lena Smirnova,Thomas Steger-Hartmann,Danilo A. Tagle,Alexander G. Tonevitsky,Tsyb S,Trapecar M,van de Water B,Van den Eijnden-van Raaij J,Paul Vulto,Watanabe K,Wolf A,Zhou X,Adrian Roth +45 more
TL;DR: It is found that the level of qualification of MPS-based assays for a given context of use and communication gaps between stakeholders are the major challenges slowing industrial adoption by end users, which in turn is causing a regulatory acceptance dilemma.
Journal ArticleDOI
Viral Vectors: The Road to Reducing Genotoxicity.
Rhiannon David,Ann T. Doherty +1 more
TL;DR: There is not a 'one size fits all' approach to vector modification for reducing genotoxicity, and addressing these challenges will be a key step in the development of therapies such as CRISPR-Cas9 and delivery of future gene-editing technologies.
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Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3
Saroor A. A. Patel,Upinder Bhambra,M P Charalambous,Rhiannon David,R J Edwards,Tracy Lightfoot,Alan R. Boobis,Nigel J. Gooderham +7 more
TL;DR: Colonic inflammation with the presence of IL6 associated with neoplastic tissue can alter metabolic competency of epithelial cells by manipulating CYP2E1 and CYP1B1 expression through transcriptional and epigenetic mechanisms, thus promoting colorectal carcinogenesis.
Journal ArticleDOI
Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis.
TL;DR: In this paper, a case-control study comparing women with polycystic ovarian syndrome (PCOS) to age and weight matched controls (n) without PCOS was performed, and miR-93 and miRNA-223 were determined by total RNA reverse transcription.