P
P.J. Talmud
Researcher at University College London
Publications - 50
Citations - 4928
P.J. Talmud is an academic researcher from University College London. The author has contributed to research in topics: Apolipoprotein B & Cholesterol. The author has an hindex of 30, co-authored 50 publications receiving 4621 citations.
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Journal ArticleDOI
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
Daniel I. Swerdlow,Michael V. Holmes,Karoline Kuchenbaecker,Engmann Jel.,Tina Shah,Reecha Sofat,Yiran Guo,C Chung,Anne Peasey,Roman Pfister,Simon P. Mooijaart,Helen Ireland,Maarten Leusink,Claudia Langenberg,KaWah Li,Jutta Palmen,Phil Howard,Jackie A. Cooper,Fotios Drenos,John Hardy,Mike A. Nalls,Yun Li,Gordon D.O. Lowe,Marlene C. W. Stewart,S. J. Bielinski,Julian Peto,Nicholas J. Timpson,John Gallacher,Malcolm G. Dunlop,Richard S. Houlston,Ian Tomlinson,Ioanna Tzoulaki,Jian'an Luan,Boer Jma.,Nita G. Forouhi,N. C. Onland-Moret,Y. T. van der Schouw,Renate B. Schnabel,Jaroslav A. Hubacek,Růžena Kubínová,Migle Baceviciene,Abdonas Tamosiunas,Andrzej Pajak,Roman Topor-Madry,Sofia Malyutina,Damiano Baldassarre,Bengt Sennblad,Elena Tremoli,U de Faire,Luigi Ferrucci,S Bandenelli,Tetsu Tanaka,James F. Meschia,AB Singleton,Gerjan Navis,I. Mateo Leach,Bakker Sjl.,Ron T. Gansevoort,Ian Ford,Stephen E. Epstein,Mary-Susan Burnett,Joe Devaney,Johan Wouter Jukema,Westendorp Rgj.,G Jan de Borst,Y. van der Graaf,P A de Jong,Mailand-van der Zee A-H.,Olaf H. Klungel,A. de Boer,P. A. Doevendans,Jeffrey W. Stephens,Charles B. Eaton,Jennifer G. Robinson,JoAnn E. Manson,F G Fowkes,Timothy M. Frayling,Jenna Price,Peter H. Whincup,Richard W Morris,Debbie A Lawlor,George Davey Smith,Yoav Ben-Shlomo,Susan Redline,Leslie A. Lange,Meena Kumari,Nicholas J. Wareham,Verschuren Wmm.,Emelia J. Benjamin,John C. Whittaker,Anders Hamsten,Frank Dudbridge,Delaney Jac.,Andrew Wong,Diana Kuh,Rebecca Hardy,Berta Almoguera Castillo,John Connolly,P. van der Harst,Eric J. Brunner,Michael Marmot,Christina L. Wassel,Steve E. Humphries,P.J. Talmud,Mika Kivimäki,Folkert W. Asselbergs,Mikhail I. Voevoda,Martin Bobak,Hynek Pikhart,James G. Wilson,Hakon Hakonarson,Alexander P. Reiner,Brendan J. Keating,Naveed Sattar,Aroon D. Hingorani,Juan P. Casas +115 more
TL;DR: IL6R blockade could provide a novel therapeutic approach to prevention of coronary heart disease that warrants testing in suitably powered randomised trials and could help to validate and prioritise novel drug targets or to repurpose existing agents and targets for new therapeutic uses.
Journal ArticleDOI
Triglyceride-mediated pathways and coronary disease : collaborative analysis of 101 studies
Nadeem Sarwar,Manjinder S. Sandhu,Sally L. Ricketts,Adam S. Butterworth,E Di Angelantonio,S. M Boekholdt,Willem H. Ouwehand,Hugh Watkins,Nilesh J. Samani,Danish Saleheen,Debbie A Lawlor,Muredach P. Reilly,Aroon D. Hingorani,P.J. Talmud,John Danesh +14 more
TL;DR: Data from a genetic variant that regulates triglyceride concentration are consistent with a causal association between triglyceride-mediated pathways and coronary heart disease.
Journal ArticleDOI
Human gene for physical performance
Hugh Montgomery,Richard P. Marshall,Harry Hemingway,Saul G. Myerson,P. Clarkson,C T Dollery,Martin Hayward,D. E. Holliman,Mick Jubb,E L Thomas,Audrey E. Brynes,N. Saeed,Maria Barnard,Jimmy D. Bell,K Prasad,Mark P. Rayson,P.J. Talmud,S.E. Humphries +17 more
TL;DR: It is shown that a polymorphism in the gene encoding angiotensin-converting enzyme is associated with elite endurance performance among high-altitude mountaineers and after physical training, repetitive weight-lifting is improved eleven-fold in individuals homozygous for the ‘insertion’ allele.
Journal ArticleDOI
Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: report of the thirty-person/ten-country panel.
Philip J. Barter,Christie M. Ballantyne,Rafael Carmena,M. Castro Cabezas,M. John Chapman,Patrick Couture,J. de Graaf,Paul N. Durrington,Ole Faergeman,Jiri Frohlich,C. D. Furberg,Claude Gagné,S. M. Haffner,S.E. Humphries,Ingmar Jungner,Ronald M. Krauss,Peter O. Kwiterovich,Santica M. Marcovina,Christopher J. Packard,Thomas A. Pearson,K. Srinath Reddy,Robert S. Rosenson,Nizal Sarrafzadegan,Allan D. Sniderman,Anton F. H. Stalenhoef,Evan A. Stein,P.J. Talmud,Andrew Tonkin,Göran Walldius,K M S Williams +29 more
TL;DR: Evidence from fundamental, epidemiological and clinical trial studies indicates that apo B is superior to any of the cholesterol indices to recognize those at increased risk of vascular disease and to judge the adequacy of lipid‐lowering therapy.
Journal ArticleDOI
Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training.
Hugh Montgomery,Peter Clarkson,Clare M. Dollery,K Prasad,Maria Angela Losi,Harry Hemingway,Deborah Statters,Mick Jubb,Martin Girvain,Amanda Varnava,John E. Deanfield,P.J. Talmud,Jean R. McEwan,William J. McKenna,Stephen E. Humphries +14 more
TL;DR: Exercise-induced LV growth in young males is strongly associated with the ACE I/D polymorphism, and the prevalence of electrocardiographically defined LVH rose significantly only among those of DD genotype.