Francesco Cipollone

TL;DR: A model of human prostaglandin endoperoxide synthase-2 expression allowing the assessment of pharmacological inhibition in vitro and ex vivo was characterized and cyclooxygenase activity increased in parallel with the mass of a monocyte protein doublet analyzed by Western blot using antibodies directed against the carboxyl-terminal portion of human PGHS-2.

TL;DR: It is demonstrated in humans that RAGE overexpression is associated with enhanced inflammatory reaction and COX-2/mPGES-1 expression in diabetic plaque macrophages, and this effect may contribute to plaque destabilization by inducing culprit metalloproteinase expression.

TL;DR: This study provides evidence that synthesis of COX-2 and PGES by activated macrophages is associated with acute ischemic syndromes, possibly through metalloproteinase-induced plaque rupture.

TL;DR: It is concluded that the in vivo formation of the F2-isoprostane 8-epi-PGF2α is enhanced in the vast majority of patients with hypercholesterolemia and dose-dependent suppression of enhanced 8-Epi- PGF2 α formation by vitamin E supplementation may contribute to the beneficial effects of antioxidant treatment.

TL;DR: It is found that the -765G-->C polymorphism of the COX-2 gene is associated with a decreased risk of MI and stroke and detection of this genotype may be useful for predicting genetic risk ofMI and stroke.