Francesco E. Pontieri

TL;DR: A key role for NMS in the clinical frame of PD is supported and the need to address them specifically in clinical trials using dedicated scales is addressed.

TL;DR: It is reported that intravenous nicotine in the rat, at doses known to maintain self-administration, stimulates local energy metabolism, as measured by 2-deoxyglucose autoradiography, and dopamine transmission, as estimated by brain microdialysis, in the shell of the nucleus accumbens.

TL;DR: Delta9-THC and heroin exert similar effects on mesolimbic dopamine transmission through a common mu1 opioid receptor mechanism located in the ventral mesencephalic tegmentum.

TL;DR: In vivo neurochemical evidence is provided for a functional compartmentation within the nucleus accumbens and for a preferential effect of psychostimulants and morphine in the shell of the nucleus Accumbens at doses known to sustain intravenous drug self-administration.

TL;DR: Parkinson-associated physiopathological modifications were characterized in six subcortical structures by simultaneously measuring quantitative magnetic resonance parameters sensitive to complementary tissue characteristics, demonstrating that multimodal magnetic resonance imaging of sub cortical grey matter structures is useful for the evaluation of Parkinson's disease and, possibly, of other subcortsical pathologies.