O
Olli Pietilainen
Researcher at Broad Institute
Publications - 21
Citations - 3011
Olli Pietilainen is an academic researcher from Broad Institute. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 12, co-authored 20 publications receiving 2544 citations. Previous affiliations of Olli Pietilainen include University of Helsinki & Wellcome Trust Sanger Institute.
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Journal ArticleDOI
Common variants conferring risk of schizophrenia
Hreinn Stefansson,Hreinn Stefansson,Roel A. Ophoff,Roel A. Ophoff,Roel A. Ophoff,Stacy Steinberg,Stacy Steinberg,Ole A. Andreassen,Sven Cichon,Dan Rujescu,Thomas Werge,Olli Pietilainen,Ole Mors,Preben Bo Mortensen,Engilbert Sigurdsson,Omar Gustafsson,Mette Nyegaard,Annamari Tuulio-Henriksson,Andres Ingason,Thomas Hansen,Jaana Suvisaari,Jouko Lönnqvist,Tiina Paunio,Anders D. Børglum,Anders D. Børglum,Annette M. Hartmann,Anders Fink-Jensen,Merete Nordentoft,David M. Hougaard,Bent Nørgaard-Pedersen,Yvonne Böttcher,Jes Olesen,René Breuer,Hans-Jürgen Möller,Ina Giegling,Henrik B. Rasmussen,Sally Timm,Manuel Mattheisen,István Bitter,János Réthelyi,Brynja B. Magnusdottir,Thordur Sigmundsson,Pall I. Olason,Gisli Masson,Jeffrey R. Gulcher,Magnús Haraldsson,Ragnheidur Fossdal,Thorgeir E. Thorgeirsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Mirella Ruggeri,Sarah Tosato,Barbara Franke,Eric Strengman,Lambertus A. Kiemeney,Ingrid Melle,Srdjan Djurovic,Lilia I. Abramova,Kaleda Vg,Julio Sanjuán,Rosa de Frutos,Elvira Bramon,Evangelos Vassos,Gillian Fraser,Ulrich Ettinger,Marco Picchioni,Nicholas Walker,T. Toulopoulou,Anna C. Need,Dongliang Ge,Joeng Lim Yoon,Kevin V. Shianna,Nelson B. Freimer,Rita M. Cantor,Robin M. Murray,Augustine Kong,Vera Golimbet,Angel Carracedo,Celso Arango,Javier Costas,Erik G. Jönsson,Lars Terenius,Ingrid Agartz,Hannes Petursson,Markus M. Nöthen,Marcella Rietschel,Paul M. Matthews,Pierandrea Muglia,Leena Peltonen,David St Clair,David Goldstein,Kari Stefansson,Kari Stefansson,David A. Collier,David A. Collier +94 more
TL;DR: Findings implicating the MHC region are consistent with an immune component to schizophrenia risk, whereas the association with NRGN and TCF4 points to perturbation of pathways involved in brain development, memory and cognition.
Journal ArticleDOI
Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders
Tarjinder Singh,Mitja I. Kurki,David Curtis,Shaun M. Purcell,Lucy Crooks,Jeremy F. McRae,Jaana Suvisaari,Himanshu Chheda,Douglas Blackwood,Gerome Breen,Olli Pietilainen,Sebastian S. Gerety,Muhammad Ayub,Moira Blyth,Trevor Cole,David Collier,Eve L. Coomber,Nicholas John Craddock,Mark J. Daly,John Danesh,Marta DiForti,Alison Foster,Nelson B. Freimer,Daniel H. Geschwind,Mandy Johnstone,Shelagh Joss,G. Kirov,Jarmo Körkkö,Outi Kuismin,Peter Holmans,Christina M. Hultman,Conrad Iyegbe,Jouko Lönnqvist,Minna Männikkö,Steve McCarroll,Peter McGuffin,Andrew M. McIntosh,Andrew McQuillin,Jukka S. Moilanen,Carmel Moore,Robin M. Murray,Ruth Newbury-Ecob,Willem H. Ouwehand,Tiina Paunio,Elena Prigmore,Elliott Rees,David J. Roberts,Jennifer G. Sambrook,Pamela Sklar,David St Clair,Juha Veijola,James T.R. Walters,Hywel Williams,Swedish Schizophrenia Study,Interval Study,Ddd Study,Patrick Sullivan,Matthew E. Hurles,Michael Conlon O'Donovan,Aarno Palotie,Michael J. Owen,Jeffrey C. Barrett +61 more
TL;DR: In this article, the authors found a genome-wide significant association between rare loss-of-function (LoF) variants in SETD1A and risk for schizophrenia (P = 3.3 × 10−9).
Journal ArticleDOI
Common variants at VRK2 and TCF4 conferring risk of schizophrenia
Stacy Steinberg,Simone de Jong,Ole A. Andreassen,Thomas Werge,Anders D. Børglum,Ole Mors,Preben Bo Mortensen,Omar Gustafsson,Omar Gustafsson,Javier Costas,Olli Pietilainen,Ditte Demontis,Sergi Papiol,Johanna Huttenlocher,Manuel Mattheisen,René Breuer,Evangelos Vassos,Ina Giegling,Gillian Fraser,Nicholas Walker,Annamari Tuulio-Henriksson,Jaana Suvisaari,Jouko Lönnqvist,Tiina Paunio,Ingrid Agartz,Ingrid Melle,Srdjan Djurovic,Eric Strengman,Gesche Jürgens,Birte Glenthøj,Lars Terenius,David M. Hougaard,Torben F. Ørntoft,Carsten Wiuf,Michael Didriksen,Mads V. Hollegaard,Merete Nordentoft,Ruud van Winkel,Gunter Kenis,Lilia I. Abramova,Kaleda Vg,Manuel Arrojo,Julio Sanjuán,Celso Arango,Swetlana Sperling,Moritz J. Rossner,Michele Ribolsi,Valentina Magni,Alberto Siracusano,Claus Christiansen,Lambertus A. Kiemeney,Jan H. Veldink,Leonard H. van den Berg,Andres Ingason,Pierandrea Muglia,Robin M. Murray,Markus M. Nöthen,Engilbert Sigurdsson,Hannes Petursson,Unnur Thorsteinsdottir,Augustine Kong,I. Alex Rubino,Marc De Hert,János Réthelyi,István Bitter,Erik G. Jönsson,Vera Golimbet,Angel Carracedo,Hannelore Ehrenreich,Nicholas John Craddock,Michael John Owen,Michael Conlon O'Donovan,Mirella Ruggeri,Sarah Tosato,Leena Peltonen,Roel A. Ophoff,David A. Collier,David St Clair,Marcella Rietschel,Sven Cichon,Hreinn Stefansson,Dan Rujescu,Kari Stefansson +82 more
TL;DR: An expanded set of variants in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), and two novel variants showing genome-wide significant association are found.
Journal ArticleDOI
C9orf72 suppresses systemic and neural inflammation induced by gut bacteria.
Aaron Burberry,Aaron Burberry,Michael F. Wells,Michael F. Wells,Francesco Limone,Francesco Limone,Francesco Limone,Alexander Couto,Alexander Couto,Kevin S. Smith,Kevin S. Smith,James Keaney,Gaëlle Gillet,Nick van Gastel,Jin-Yuan Wang,Jin-Yuan Wang,Olli Pietilainen,Olli Pietilainen,Menglu Qian,Menglu Qian,Pierce Eggan,Pierce Eggan,Christopher Cantrell,Christopher Cantrell,Joanie Mok,Joanie Mok,Irena Kadiu,David T. Scadden,Kevin Eggan,Kevin Eggan +29 more
TL;DR: Reduced abundance of immune-stimulating gut bacteria ameliorated the inflammatory and autoimmune phenotypes of mice with mutations in C9orf72, which in the human orthologue are linked to amyotrophic lateral sclerosis and frontotemporal dementia.
Journal ArticleDOI
Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission
Ralda Nehme,Ralda Nehme,Emanuela Zuccaro,Emanuela Zuccaro,Sulagna Ghosh,Sulagna Ghosh,Chenchen Li,John L. Sherwood,John L. Sherwood,Olli Pietilainen,Olli Pietilainen,Lindy E. Barrett,Lindy E. Barrett,Francesco Limone,Francesco Limone,Kathleen A. Worringer,Sravya Kommineni,Ying Zang,Davide Cacchiarelli,Alexander Meissner,Rolf Adolfsson,Stephen J. Haggarty,Jon M. Madison,Matthias Müller,Paola Arlotta,Paola Arlotta,Zhanyan Fu,Guoping Feng,Guoping Feng,Kevin Eggan,Kevin Eggan +30 more
TL;DR: Transcription factor programming of pluripotent stem cells (PSCs) has emerged as an approach to generate human neurons for disease modeling as discussed by the authors, however, programming schemes produce a variety of cell types.