J
Jean Christophe Barale
Researcher at Pasteur Institute
Publications - 10
Citations - 2170
Jean Christophe Barale is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Plasmodium falciparum & Artemisinin. The author has an hindex of 4, co-authored 7 publications receiving 1860 citations. Previous affiliations of Jean Christophe Barale include Centre national de la recherche scientifique & University of Paris.
Papers
More filters
Journal ArticleDOI
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
Frédéric Ariey,Benoit Witkowski,Chanaki Amaratunga,Johann Beghain,Anne-Claire Langlois,Nimol Khim,Saorin Kim,Valentine Duru,Christiane Bouchier,Laurence Ma,Pharath Lim,Rithea Leang,Socheat Duong,Sokunthea Sreng,Seila Suon,Char Meng Chuor,Denis Mey Bout,Sandie Menard,William O. Rogers,Blaise Genton,Thierry Fandeur,Olivo Miotto,Pascal Ringwald,Jacques Le Bras,Antoine Berry,Jean Christophe Barale,Rick M. Fairhurst,Françoise Benoit-Vical,Odile Mercereau-Puijalon,Didier Menard +29 more
TL;DR: Strong correlations between the presence of a mutant allele, in vitro parasite survival rates and in vivo parasite clearance rates indicate that K13-propeller mutations are important determinants of artemisinin resistance.
Journal ArticleDOI
A Worldwide Map of Plasmodium Falciparum K13-Propeller Polymorphisms
Didier Menard,Nimol Khim,Johann Beghain,Ayola A. Adegnika,Ayola A. Adegnika,Mohammad Shafiul-Alam,Olukemi K. Amodu,Ghulam Rahim-Awab,Ghulam Rahim-Awab,Céline Barnadas,Céline Barnadas,Céline Barnadas,Antoine Berry,Yap Boum,Yap Boum,Maria Dorina Bustos,Jun Cao,Jun Hu Chen,Louis Collet,Liwang Cui,Garib Das Thakur,Alioune Dieye,Alioune Dieye,Djibrine Djalle,Monique A. Dorkenoo,Carole E. Eboumbou-Moukoko,Fe Espino,Thierry Fandeur,Maria de Fátima Ferreira-da-Cruz,Abebe A. Fola,Abebe A. Fola,Hans-Peter Fuehrer,Abdillahi Mohamed Hassan,Sócrates Herrera,Bouasy Hongvanthong,Sandrine Houzé,Maman Laminou Ibrahim,Mohammad Jahirul-Karim,Lubin Jiang,Shigeyuki Kano,Wasif Ali-Khan,Maniphone Khanthavong,Peter G. Kremsner,Marcus V. G. Lacerda,Rithea Leang,Mindy Leelawong,Mei Li,Khin Lin,Jean Baptiste Mazarati,Sandie Menard,Isabelle Morlais,Hypolite Muhindo-Mavoko,Hypolite Muhindo-Mavoko,Lise Musset,Kesara Na-Bangchang,Michael Nambozi,Karamoko Niaré,Harald Noedl,Jean-Bosco Ouédraogo,Dylan R. Pillai,Bruno Pradines,Bui Quang-Phuc,Michael Ramharter,Michael Ramharter,Milijaona Randrianarivelojosia,Jetsumon Sattabongkot,Abdiqani Sheikh-Omar,Kigbafori D. Silué,Sodiomon B. Sirima,Colin J. Sutherland,Din Syafruddin,Rachida Tahar,Lin Hua Tang,Offianan Andre Toure,Patrick Tshibangu-Wa-Tshibangu,Inès Vigan-Womas,Marian Warsame,Lyndes Wini,Sedigheh Zakeri,Saorin Kim,Rotha Eam,Laura Berne,Chanra Khean,Sophy Chy,Malen Ken,Kaknika Loch,Lydie Canier,Valentine Duru,Eric Legrand,Jean Christophe Barale,Barbara H. Stokes,Judith Straimer,Benoit Witkowski,David A. Fidock,Christophe Rogier,Pascal Ringwald,Frédéric Ariey,Odile Mercereau-Puijalon +97 more
TL;DR: In this article, the authors analyzed the K13-propeller sequence polymorphism in 14,037 samples collected in 59 countries in which malaria is endemic and identified 108 nonsynonymous K13 mutations, which showed marked geographic disparity in their frequency and distribution.
Journal ArticleDOI
CyProQuant-PCR: a real time RT-PCR technique for profiling human cytokines, based on external RNA standards, readily automatable for clinical use
Philippe Boeuf,Inès Vigan-Womas,Delphine Jublot,Séverine Loizon,Jean Christophe Barale,Bartholomew D. Akanmori,Odile Mercereau-Puijalon,Charlotte Behr +7 more
TL;DR: The real-time RT-PCR technique based on a RNA standard curve, CyPro Quantitative PCR, allows for a genuine absolute quantification and a simultaneous analysis of a large panel of human cytokine mRNA and represents a potent and attractive tool for immunomonitoring.
Journal ArticleDOI
LANCL1, an erythrocyte protein recruited to the Maurer's clefts during Plasmodium falciparum development.
Thierry Blisnick,Laetitia Vincensini,Jean Christophe Barale,Jean Christophe Barale,Abdelkader Namane,Catherine Braun Breton,Catherine Braun Breton +6 more
TL;DR: It is proposed that the interaction between PfSBP1 and LANCL1 is central for late steps of the parasite development to prevent premature rupture of the red blood cell membrane.
Journal ArticleDOI
In vitro activity of ferroquine against artemisinin-based combination therapy (ACT)-resistant Plasmodium falciparum isolates from Cambodia
Melissa Mairet-Khedim,Flore Nardella,Nimol Khim,Saorin Kim,Nimol Kloeung,Sopheakvatey Ke,Chhayleang Kauy,Rotha Eam,Chanra Khean,Alain Pellet,Didier Leboulleux,Rithea Leang,Pascal Ringwald,Jean Christophe Barale,Jean Christophe Barale,Didier Leroy,Didier Menard,Benoit Witkowski +17 more
TL;DR: Ferroquine exerts promising efficacy against ACT-resistant isolates, and the susceptibility range observed was in accordance with those measured in ACT resistance-free areas, which enables consideration of ferroquines as a relevant therapeutic option againstACT-resistant malaria.